Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques, Université Paris Descartes, Sorbonne Paris Cité, CNRS UMR 860, 45, rue des Saints Pères, 75006 Paris, France.
Org Lett. 2011 Oct 21;13(20):5660-3. doi: 10.1021/ol202380q. Epub 2011 Sep 30.
The first four members of a new family of C(3v)-symmetrical "two-story" calix[6]aza-cryptands have been synthesized. These large funnel shaped aza-ligands are formed through introduction of three aromatic arms as spacers onto the small rim of a calix[6]arene and subsequently capped with the tripodal aza caps tacn [1,3,5-triazacyclononane] or tren [tris(aminoethyl)amine]. A key feature for an efficient final 1:1 macrocyclization appears to be an adequate geometrical fit between the extended calixarene scaffold and the aza caps.
已经合成了新型 C(3v)-对称“两层”杯[6]氮杂冠醚的前四个成员。这些大型漏斗状的氮杂配体是通过在杯[6]芳烃的小边缘上引入三个芳基臂作为间隔基，并随后用三脚架氮杂 caps tacn [1,3,5-三氮杂环壬烷]或 tren [三(氨基乙基)胺]封端来形成的。对于有效的最终 1:1 大环化，一个关键特征似乎是扩展杯芳烃支架和氮杂帽之间的适当几何拟合。
