相似文献
1
Design and synthesis of a novel tyrosine kinase inhibitor template.
Bioorg Med Chem. 2009 May 1;17(9):3308-16. doi: 10.1016/j.bmc.2009.03.046. Epub 2009 Mar 27.
2
Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.
Bioorg Med Chem Lett. 2011 Aug 1;21(15):4592-6. doi: 10.1016/j.bmcl.2011.05.103. Epub 2011 Jun 12.
3
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.
Mol Cancer Ther. 2009 Oct;8(10):2811-20. doi: 10.1158/1535-7163.MCT-09-0423.
4
Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors.
ChemMedChem. 2011 Sep 5;6(9):1680-92. doi: 10.1002/cmdc.201100168. Epub 2011 Jun 30.
5
Design, synthesis and biological evaluations of 2-amino-4-(1-piperidine) pyridine derivatives as novel anti crizotinib-resistant ALK/ROS1 dual inhibitors.
Eur J Med Chem. 2019 Oct 1;179:358-375. doi: 10.1016/j.ejmech.2019.06.043. Epub 2019 Jun 25.
6
Design, synthesis, and anaplastic lymphoma kinase (ALK) inhibitory activity for a novel series of 2,4,8,22-tetraazatetracyclo[14.3.1.1³,⁷.1⁹,¹³]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene macrocycles.
J Med Chem. 2012 Jan 12;55(1):449-64. doi: 10.1021/jm201333e. Epub 2011 Dec 15.
7
Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening.
J Med Chem. 2010 Mar 25;53(6):2661-5. doi: 10.1021/jm901798e.
8
Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase.
Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. doi: 10.1016/j.bmc.2010.04.087. Epub 2010 Apr 29.
9
A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor.
J Biol Chem. 2013 Sep 27;288(39):28068-77. doi: 10.1074/jbc.M113.505032. Epub 2013 Aug 9.
10
Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline.
Bioorg Med Chem Lett. 2011 Aug 15;21(16):4702-4. doi: 10.1016/j.bmcl.2011.06.090. Epub 2011 Jun 25.
引用本文的文献
1
ALK inhibitors: a new targeted therapy in the treatment of advanced NSCLC.
Target Oncol. 2013 Mar;8(1):55-67. doi: 10.1007/s11523-012-0250-9. Epub 2013 Jan 17.
2
ALK and NSCLC: Targeted therapy with ALK inhibitors.
F1000 Med Rep. 2011;3:21. doi: 10.3410/M3-21. Epub 2011 Nov 1.
本文引用的文献
1
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
Nature. 2008 Oct 16;455(7215):975-8. doi: 10.1038/nature07397.
2
Generation of new synthetic scaffolds using framework libraries selected and refined via medicinal chemist synthetic expertise.
J Chem Inf Model. 2008 Apr;48(4):882-8. doi: 10.1021/ci7001928. Epub 2008 Mar 13.
3
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.
Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22. doi: 10.1158/1535-7163.MCT-07-0365.
4
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41. doi: 10.1073/pnas.0707498104. Epub 2007 Dec 6.
5
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
J Med Chem. 2007 Oct 18;50(21):5090-102. doi: 10.1021/jm0704548. Epub 2007 Sep 19.
6
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.
Cancer Res. 2007 May 1;67(9):4408-17. doi: 10.1158/0008-5472.CAN-06-4443.
7
Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile.
Bioorg Med Chem Lett. 2007 Jun 1;17(11):3072-6. doi: 10.1016/j.bmcl.2007.03.048. Epub 2007 Mar 19.
8
Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate.
J Org Chem. 2006 Dec 8;71(25):9420-30. doi: 10.1021/jo0617666.
9
Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors.
Bioorg Med Chem Lett. 2006 Nov 15;16(22):5907-12. doi: 10.1016/j.bmcl.2006.08.053. Epub 2006 Sep 20.
10
Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.
Org Lett. 2006 Sep 28;8(20):4473-5. doi: 10.1021/ol061617+.
Zotero 插件