Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.
作者信息
Opatz Till, Ferenc Dorota
机构信息
Institut für Organische Chemie, Universität Mainz, Duesbergweg 10-14, D-55128 Mainz, Germany.
出版信息
Org Lett. 2006 Sep 28;8(20):4473-5. doi: 10.1021/ol061617+.
PMID:16986928
Abstract
Alpha-Aminonitriles derived from 2-aminocinnamic acid esters and amides can be cyclized under basic conditions to furnish substituted indole-3-acetic acid derivatives in quantitative yield. The reaction provides a simple access to a class of biologically active compounds.
摘要
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