Kurjak A, Kupesic-Urek S, Schulman H, Zalud I
Ultrasonic Institute, University of Zagreb, Yugoslavia.
Fertil Steril. 1991 Nov;56(5):870-3. doi: 10.1016/s0015-0282(16)54657-3.
To measure the flow velocity of the uterine and ovarian arteries through the menstrual cycle to determine there are changes.
Serial measurements throughout the menstrual cycle in women attending an infertility clinic, compared with volunteers coming for annual examinations. Transvaginal ultrasound-color flow Doppler was the investigative tool.
A University Hospital ambulatory care center.
One hundred infertile women compared with 150 women attending the clinic for annual checkups.
Changes in the resistance index of flow velocity waveforms of the uterine and ovarian arteries.
Uterine flow velocity has a resistance index of 0.88 +/- 0.04 (2 SE) in the proliferative phase and starts to decrease the day before ovulation. A nadir of 0.84 +/- 0.04 is reached on day 18 and remains at that level for the rest of the cycle. In anovulatory cycles, these changes do not occur. A subgroup of 12 women who lacked end diastolic flow in the uterine arteries during the secretory phase were identified. Eleven of these women were infertile, 8 of whom with primary infertility. Ovarian artery flow velocity is usually detected when the dominant follicle reaches 12 to 15 mm. The resistance index is 0.54 +/- 0.04 and also declines on the day before ovulation. A nadir of 0.44 +/- 0.04 is reached 4 to 5 days later and slowly rises to 0.050 +/- 0.04 before menstruation.
There are changes in the flow velocity patterns of the uterine and ovarian arteries during the normal ovulatory menstrual cycle. Because these changes in flow velocity begin before ovulation, it can be suspected that they may involve angiogenesis as well as hormonal factors. The changes noted in these studies are statistically significant but may be too small to be used as a diagnostic tool in the study of infertility problems.
通过整个月经周期测量子宫和卵巢动脉的血流速度，以确定是否存在变化。
在一家不孕不育诊所就诊的女性中，在整个月经周期进行系列测量，并与前来进行年度检查的志愿者进行比较。经阴道超声彩色血流多普勒是研究工具。
一家大学医院门诊护理中心。
100名不孕女性与150名到诊所进行年度检查的女性。
子宫和卵巢动脉血流速度波形阻力指数的变化。
增殖期子宫血流速度的阻力指数为0.88±0.04（2个标准误），在排卵前一天开始下降。在第18天达到最低点0.84±0.04，并在周期的其余时间保持在该水平。在无排卵周期中，这些变化不会发生。确定了一个在分泌期子宫动脉缺乏舒张末期血流的12名女性亚组。这些女性中有11名不孕，其中8名是原发性不孕。当优势卵泡达到12至15毫米时，通常可检测到卵巢动脉血流速度。阻力指数为0.54±0.04，在排卵前一天也会下降。4至5天后达到最低点0.44±0.04，在月经前缓慢上升至0.50±0.04。
在正常排卵月经周期中，子宫和卵巢动脉的血流速度模式存在变化。由于这些血流速度变化在排卵前就开始了，可以怀疑它们可能涉及血管生成以及激素因素。这些研究中观察到的变化具有统计学意义，但可能太小，无法用作不孕问题研究的诊断工具。
