Ismail Ayman M, Padrick Shae B, Chen Baoyu, Umetani Junko, Rosen Michael K
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, USA.
Nat Struct Mol Biol. 2009 May;16(5):561-3. doi: 10.1038/nsmb.1587. Epub 2009 Apr 12.
The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.
WAVE调节复合体（WRC）将信息从Rac GTP酶传递给肌动蛋白成核因子Arp2/3复合体。我们已经以多种形式重组了重组人源和果蝇WRC，并表明它们对Arp2/3复合体无活性，但可以被Rac以核苷酸依赖的方式激活。我们的观察结果确定了WAVE抑制所需的核心成分，调和了相互矛盾的现有机制，并揭示了WAVE/WASP蛋白家族的共同调节原则。
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