WAVE信号传导：从生物化学到生物学
WAVE signalling: from biochemistry to biology.
作者信息
Soderling S H, Scott J D
机构信息
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
出版信息
Biochem Soc Trans. 2006 Feb;34(Pt 1):73-6. doi: 10.1042/BST0340073.
The small GTPases Rho, Rac and Cdc42 (cell-division cycle 42) function as molecular switches to modulate the actin cytoskeleton. They achieve this by modulating the activity of downstream cellular targets. One group of Rho GTPase effectors, WAVE (Wiskott-Aldrich syndrome protein verprolin homologous)-1, WAVE-2 and WAVE-3, function as scaffolds for actin-based signalling complexes. The present review highlights current knowledge regarding the biochemistry of the WAVE signalling complexes and their biological significance.
小GTP酶Rho、Rac和Cdc42（细胞分裂周期蛋白42）作为分子开关来调节肌动蛋白细胞骨架。它们通过调节下游细胞靶点的活性来实现这一点。Rho GTP酶效应器的一个家族，WAVE（威斯科特-奥尔德里奇综合征蛋白维普洛林同源物）-1、WAVE-2和WAVE-3，作为基于肌动蛋白的信号复合物的支架发挥作用。本综述重点介绍了关于WAVE信号复合物的生物化学及其生物学意义的当前知识。
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