De Luis D A, Conde R, Aller R, Izaola O, González Sagrado M, Perez Castrillón J L, Dueñas A, Romero E
Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.
Eur Rev Med Pharmacol Sci. 2009 Jan-Feb;13(1):51-5.
Epidemiological and interventional studies suggest that a high dietary intake of n-3 polyunsaturated fatty acids may confer a protective effect against atherosclerotic disease and reduce serum triglycerides levels. The aim of our study was to investigate the effectivity on triglyceride levels and inflammatory markers of a concentrated of n-3 fatty acids in patients with type 2 diabetes mellitus and hypertriglyceridaemia.
A total of 30 patients (16 males and 14 females) with diabetes mellitus type 2 and hypertriglyceridemia (> 200 mg/dl) were included in the study. Patients received two capsules of eicosapentaenoic 465 mg and docosahexanoic 375 mg daily for 12 weeks.
Triglycerides levels and non HDL-cholesterol decreased (326 +/- 113.5 vs. 216.4 +/- 57 mg/dl; p < 0.05) and (103.87 +/- 44 vs. 89.6 +/- 14 mg/dl; p < 0.05), respectively. HDL-cholesterol levels increased (39.6 +/- 10.7 vs. 46.4 +/- 8.7 mg/dl; p < 0.05). C reactive protein decreased (5.98 +/- 3.9 vs. 3.9 +/- 1.6 mg/dl; p < 0.05) and TNF-alpha levels decreased (16.24 +/- 5.5 vs. 13.3 +/- 5.8 pg/dl; p < 0.05), without significant changes in IL-6 levels. In conclusion, an n-3 polyunsaturated intervention improved lipid profile and inflammatory markers in patients with diabetes mellitus type 2 and hypertriglyceridaemia.
流行病学和干预性研究表明，高膳食摄入n-3多不饱和脂肪酸可能对动脉粥样硬化疾病具有保护作用，并降低血清甘油三酯水平。我们研究的目的是探讨n-3脂肪酸浓缩物对2型糖尿病和高甘油三酯血症患者甘油三酯水平和炎症标志物的有效性。
本研究共纳入30例2型糖尿病和高甘油三酯血症（>200mg/dl）患者（16例男性和14例女性）。患者每天服用两粒胶囊，其中二十碳五烯酸465mg，二十二碳六烯酸375mg，持续12周。
甘油三酯水平和非高密度脂蛋白胆固醇分别下降（326±113.5 vs. 216.4±57mg/dl；p<0.05）和（103.87±44 vs. 89.6±14mg/dl；p<0.05）。高密度脂蛋白胆固醇水平升高（39.6±10.7 vs. 46.4±8.7mg/dl；p<0.05）。C反应蛋白下降（5.98±3.9 vs. 3.9±1.6mg/dl；p<0.05），肿瘤坏死因子-α水平下降（16.24±5.5 vs. 13.3±5.8pg/dl；p<0.05），白细胞介素-6水平无显著变化。总之，n-3多不饱和脂肪酸干预改善了2型糖尿病和高甘油三酯血症患者的血脂谱和炎症标志物。
