Li Q, Wang Z, Zhu D, Xu M, Chen X, Peng D, Iwata Y, Xie P
Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Eur J Neurol. 2009 Mar;16(3):399-403. doi: 10.1111/j.1468-1331.2008.02516.x.
Borna disease virus (BDV) is a neurotropic RNA virus that is known to cause neurological disturbances in various animal species, potentially even humans. However, the association between BDV infection and human neurological disorders remains unclear.
Between August 2005 and March 2006, 65 patients with neurological disorders were enrolled into our study. The presence of BDV p24 RNA from peripheral blood mononuclear cells (PBMCs) was investigated by using nested reverse transcriptase PCR (RT-PCR) assay.
Borna disease virus p24 RNA was detected from PBMCs in six patients with viral encephalitis by using nested RT-PCR assay. However, BDV p24 RNA was not detected in patients with multiple sclerosis or peripheral nerve diseases.
There might be possible associations between BDV infection and human viral encephalitis.
博尔纳病病毒（BDV）是一种嗜神经性RNA病毒，已知可在多种动物物种甚至可能在人类中引起神经功能障碍。然而，BDV感染与人类神经疾病之间的关联仍不清楚。
在2005年8月至2006年3月期间，65例神经疾病患者被纳入我们的研究。通过巢式逆转录聚合酶链反应（RT-PCR）检测外周血单核细胞（PBMC）中BDV p24 RNA的存在情况。
通过巢式RT-PCR检测，在6例病毒性脑炎患者的PBMC中检测到博尔纳病病毒p24 RNA。然而，在多发性硬化症或周围神经疾病患者中未检测到BDV p24 RNA。
BDV感染与人类病毒性脑炎之间可能存在关联。
