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[皮肤异位脑膜结节]

[Cutaneous heterotopic meningeal nodules].

作者信息

Battistella Maxime, Verola Olivier, Moulonguet Isabelle, Janin Anne

机构信息

Service de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France.

出版信息

Ann Pathol. 2009 Apr;29(2):130-3. doi: 10.1016/j.annpat.2008.10.002. Epub 2009 Mar 13.

Abstract

Cutaneous heterotopic meningeal nodules are rare lesions whose pathogenesis remain discussed. They are typically located on the scalp or the rachidian axis. They often are congenital and diagnosed during childhood or young adulthood. There are two admitted theories for pathogenesis of heterotopic meningeal nodules: (1) tumoral proliferation of ectopic arachnoïdal cells (true cutaneous meningioma), (2) meningocele-type developmental defect (rudimentary meningocele). Histological and immunohistochemical aspects are characteristic, showing arachnoidal cells, EMA+ and vimentine+, that infiltrate collagene and whorl around collagene or psammomatous bodies. We report the expression of progesterone receptor (PR) in a cutaneous heterotopic meningeal nodule on the scalp of a 23-year-old man, and propose this PR expression as a new diagnosis tool for such lesions.

摘要

皮肤异位脑膜结节是一种罕见的病变,其发病机制仍存在争议。它们通常位于头皮或脊柱轴上。它们往往是先天性的,在儿童期或青年期被诊断出来。关于异位脑膜结节的发病机制有两种公认的理论:(1)异位蛛网膜细胞的肿瘤性增殖(真性皮肤脑膜瘤),(2)脑脊膜膨出型发育缺陷(原始脑脊膜膨出)。组织学和免疫组化特征明显,显示蛛网膜细胞,EMA阳性和波形蛋白阳性,浸润胶原并围绕胶原或砂粒体形成漩涡。我们报告了一名23岁男性头皮上皮肤异位脑膜结节中孕激素受体(PR)的表达,并提出这种PR表达可作为此类病变的一种新的诊断工具。

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