Güngör Sule, Gökdemir Gonca, Tarıkçı Nagehan, Sayılgan Tülay, Bek Sirzat
Dermatology Department, Okmeydanı Training and Research Hospital, İstanbul, Turkey.
Dermatol Online J. 2012 Sep 15;18(9):6.
Meningiomas are tumors of the central nervous system that rarely present as extracranial soft tissue masses. Meningioma of the skin is referred to as cutaneous meningioma. Cutaneous meningioma of the scalp is extremely rare and may cause diagnostic challenges. A 70-year-old female patient presented with a painless mass on her scalp. A punch biopsy was performed; histological examination of the specimen revealed an infiltration of spindle-shaped and epithelioid atypical cells arranged in whorls. Immunohistochemistry was positive for vimentin and epithelial membrane antigen. On magnetic resonance imaging, a large intracranial mass eroding through the skull was observed. A diagnosis of intracranial anaplastic meningioma was established and excision was performed in the Department of Neurosurgery. It is important to consider intracranial tumors in the differential diagnosis of nodules on scalp.
脑膜瘤是中枢神经系统肿瘤，很少表现为颅外软组织肿块。皮肤脑膜瘤称为皮肤型脑膜瘤。头皮皮肤型脑膜瘤极为罕见，可能带来诊断挑战。一名70岁女性患者头皮出现无痛性肿块。进行了钻孔活检；标本的组织学检查显示有呈漩涡状排列的梭形和上皮样非典型细胞浸润。免疫组化波形蛋白和上皮膜抗原呈阳性。磁共振成像显示有一个大的颅内肿块侵蚀颅骨。确诊为颅内间变性脑膜瘤，并在神经外科进行了切除。在头皮结节的鉴别诊断中考虑颅内肿瘤很重要。
