用于药物和基因递送的聚（乙二醇）-聚（氨基酸）嵌段共聚物形成的聚合物胶束
Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery.
作者信息
Osada Kensuke, Christie R James, Kataoka Kazunori
机构信息
Department of Materials Engineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
出版信息
J R Soc Interface. 2009 Jun 6;6 Suppl 3(Suppl 3):S325-39. doi: 10.1098/rsif.2008.0547.focus. Epub 2009 Apr 1.
Abstract
Dramatic advances in biological research have revealed the mechanisms underlying many diseases at the molecular level. However, conventional techniques may be inadequate for direct application of this new knowledge to medical treatments. Nanobiotechnology, which integrates biology with the rapidly growing field of nanotechnology, has great potential to overcome many technical problems and lead to the development of effective therapies. The use of nanobiotechnology in drug delivery systems (DDS) is attractive for advanced treatment of conditions such as cancer and genetic diseases. In this review paper for a special issue on biomaterial research in Japan, we discuss the development of DDS based on polymeric micelles mainly in our group for anti-cancer drug and gene delivery, and also address our challenges associated with developing polymeric micelles as super-functionalized nanodevices with intelligent performance.
摘要
生物学研究的巨大进展已在分子水平上揭示了许多疾病的潜在机制。然而，传统技术可能不足以将这些新知识直接应用于医学治疗。纳米生物技术将生物学与迅速发展的纳米技术领域相结合，具有巨大潜力来克服许多技术问题，并推动有效疗法的开发。纳米生物技术在药物递送系统（DDS）中的应用对于癌症和遗传疾病等病症的先进治疗具有吸引力。在这篇为日本生物材料研究特刊撰写的综述论文中，我们主要讨论了基于聚合物胶束的DDS在我们小组内用于抗癌药物和基因递送的发展情况，同时也阐述了我们在将聚合物胶束开发成具有智能性能的超功能化纳米器件方面所面临的挑战。
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