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基于沸石-聚乙二醇二丙烯酸酯的复合纳米凝胶用于药物控释

Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery.

作者信息

Spatarelu Catalina Paula, Radu Chiriac Anita-Laura, Cursaru Bogdan, Iordache Tanta-Verona, Gavrila Ana-Mihaela, Cojocaru Crina-Thea, Botez Razvan-Edward, Trica Bogdan, Sarbu Andrei, Teodorescu Mircea, Tofan Vlad, Perrin Francois-Xavier, Zaharia Anamaria

机构信息

Advanced Polymer Materials and Polymer Recycling Group, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 202 Spl. Independentei, 6th District, P.O. Box 35/174, 060021 Bucharest, Romania.

Department of Bioresources and Polymer Science, Faculty of Applied Chemistry and Materials Science, University "Politehnica" of Bucharest, 1-7 Gh. Polizu Street, 1st District, 011061 Bucharest, Romania.

出版信息

Nanomaterials (Basel). 2020 Jan 22;10(2):195. doi: 10.3390/nano10020195.

DOI:10.3390/nano10020195
PMID:31979174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7075022/
Abstract

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite‒nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

摘要

本研究展示了基于聚乙二醇二丙烯酸酯和天然沸石颗粒的新型复合纳米凝胶的设计，这些纳米凝胶能够作为具有可控药物递送特性的材料。通过反向微乳液技术制备了具有不同沸石含量的天然沸石-纳米凝胶复合材料，并负载了广泛使用的化疗药物5-氟尿嘧啶。在此，研究了通过改变制备条件来调节最终性能的可能性。所制备的复合纳米凝胶通过动态光散射（DLS）、透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）和热重分析（TGA）进行表征。鉴于这种可调的药物负载能力、溶胀行为和细胞毒性，这些复合纳米凝胶作为药物载体可能极具吸引力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/1310b9426ef9/nanomaterials-10-00195-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/c27b8d50d882/nanomaterials-10-00195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/e8d1d82d95da/nanomaterials-10-00195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/dbefd012cb0c/nanomaterials-10-00195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/c6c48876170a/nanomaterials-10-00195-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/93a363e22f80/nanomaterials-10-00195-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/66582a4d3c4f/nanomaterials-10-00195-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/c8595749b465/nanomaterials-10-00195-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/66db676e1992/nanomaterials-10-00195-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/59265e08c906/nanomaterials-10-00195-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/49838ee9483d/nanomaterials-10-00195-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/1310b9426ef9/nanomaterials-10-00195-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/c27b8d50d882/nanomaterials-10-00195-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/e8d1d82d95da/nanomaterials-10-00195-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/dbefd012cb0c/nanomaterials-10-00195-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/c6c48876170a/nanomaterials-10-00195-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/93a363e22f80/nanomaterials-10-00195-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/66582a4d3c4f/nanomaterials-10-00195-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/c8595749b465/nanomaterials-10-00195-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/66db676e1992/nanomaterials-10-00195-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/59265e08c906/nanomaterials-10-00195-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/49838ee9483d/nanomaterials-10-00195-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37cc/7075022/1310b9426ef9/nanomaterials-10-00195-g011.jpg

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