IMS Health Sweden AB.
J Atten Disord. 2010 May;13(6):618-28. doi: 10.1177/1087054709332163. Epub 2009 Apr 13.
To compare societal costs between patients treated with atomoxetine and placebo in Sweden.
Ninety-nine pediatric ADHD patients were randomized to a 10-week double-blind treatment with atomoxetine (n = 49) or placebo (n = 50). All parents received four sessions of psycho-education. Parents filled out a resource utilization questionnaire covering the 10 weeks prior to treatment and the 10-week on-treatment period. Published unit costs/prices were used to calculate costs.
Mean on-treatment costs in the atomoxetine group (SEK [Swedish Krona] 4,558) were significantly lower compared with placebo (SEK 7,684) after adjusting for baseline costs and site (p = .007). All 99 patients entered an open atomoxetine extension phase. Both groups had numerical reductions in direct and indirect costs while on atomoxetine treatment during the extension phase. The atomoxetine medication costs were offset by the reductions in direct nonmedical and indirect costs.
These data provide preliminary evidence that atomoxetine together with parental psycho education reduces nonmedication costs associated with ADHD in Sweden.
比较瑞典接受阿托西汀和安慰剂治疗的患者的社会成本。
99 名儿科 ADHD 患者被随机分配到为期 10 周的阿托西汀(n = 49)或安慰剂(n = 50)双盲治疗。所有父母都接受了四次心理教育课程。父母填写了一份资源利用问卷,涵盖治疗前 10 周和治疗期间的 10 周。使用公布的单位成本/价格来计算成本。
在调整基线成本和地点后,阿托西汀组(瑞典克朗 4558 瑞典克朗)的治疗期间平均成本显著低于安慰剂组(瑞典克朗 7684 瑞典克朗)(p =.007)。所有 99 名患者均进入了开放的阿托西汀扩展阶段。两组在扩展阶段接受阿托西汀治疗时,直接和间接成本均有数值上的降低。阿托西汀药物成本被直接非医疗和间接成本的降低所抵消。
这些数据初步表明,阿托西汀联合父母心理教育可降低瑞典 ADHD 的非药物相关成本。