Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
J Cardiovasc Pharmacol. 2009 Oct;54(4):273-8. doi: 10.1097/FJC.0b013e3181a1b9c7.
Congestive heart failure is a leading cause of morbidity and mortality. Congestive heart failure is marked by atrial and ventricular enlargements and reduced cardiac contractility and an association with an increased incidence of atrial and ventricular arrhythmias and sudden cardiac death. Dysfunctional ion channel function is one of the major underlying mechanisms of the reduced contractility and arrhythmias. In this review, we explore the utility of ion channels, transporters, and pumps as targets for the treatment of heart failure, focusing predominantly on the treatment for reduced contractility and arrhythmias.
充血性心力衰竭是发病率和死亡率的主要原因。充血性心力衰竭的特征是心房和心室增大，心肌收缩力降低，并与房性和室性心律失常以及心脏性猝死的发生率增加相关。离子通道功能障碍是收缩力降低和心律失常的主要潜在机制之一。在这篇综述中，我们探讨了离子通道、转运体和泵作为心力衰竭治疗靶点的应用，主要集中在治疗收缩力降低和心律失常方面。
