Rodrigues Paula, Gonçalves Carlos, Honório Ana, Barros José, Bairos Vasco
Department of Pathology and Veterinary Clinics - University of Trás-os-Montes e Alto Douro, (UTAD) Vila Real, Portugal; Center for Animal and Veterinary Sciences, UTAD, Vila Real, Portugal.
Open Respir Med J. 2008;2:46-51. doi: 10.2174/1874306400802010046. Epub 2008 May 15.
Elastic fibres play a crucial function during the process of lung alveolisation. During the perinatal period, any changes in the elastogenic process during foetal development may result in permanent lifetime defects. In pre-natal life, well-developed pulmonary elastic fibres should favor the pre-natal maturation of the lung and an enhanced alveolisation, which in many species, such as humans begins only after birth. The authors present a quantitative study by image analysis and by high-pressure liquid chromatography (HPLC) of the mouse lungs' elastic fibre content from the 15th till the 19th gestational day.
弹性纤维在肺泡形成过程中发挥着关键作用。在围产期,胎儿发育过程中弹性生成过程的任何变化都可能导致终身永久性缺陷。在出生前,发育良好的肺弹性纤维应有助于肺的产前成熟和增强肺泡化,而在许多物种中,如人类,肺泡化仅在出生后才开始。作者通过图像分析和高压液相色谱法(HPLC)对妊娠第15天至第19天小鼠肺弹性纤维含量进行了定量研究。