Pertzelan A, Blum I, Grunebaum M, Laron Z
Clin Endocrinol (Oxf). 1977 Apr;6(4):271-6. doi: 10.1111/j.1365-2265.1977.tb02011.x.
Six patients with multiple pituitary hormone deficiencies (MPHD) were initially treated with separate courses of methandrostenolone and growth hormone and later with the two drugs combined. During the basal period the mean growth velocity was 2.8 cm/year. Methandrostenolone alone, 0.02-0.05 mg/kg/day given to four of the patients led to an acceleration of the growth velocity to a mean of 5.0 cm/year, while growth hormone 6 mg/week alone accelerated the growth rate to a mean of 6.0 cm/year. Combined therapy led to a striking increase in the mean growth rate to 9.3 cm/year. The shortcoming of the combined growth hormone-androgen therapy was the fast acceleration in skeletal maturation even after short-term administration.
6例多发性垂体激素缺乏症（MPHD）患者最初分别接受美雄酮和生长激素治疗，之后接受两种药物联合治疗。在基础期，平均生长速度为每年2.8厘米。4例患者单独使用美雄酮，剂量为0.02 - 0.05毫克/千克/天，生长速度加快至平均每年5.0厘米，而单独使用生长激素6毫克/周，生长速度加快至平均每年6.0厘米。联合治疗使平均生长速度显著提高至每年9.3厘米。生长激素与雄激素联合治疗的缺点是即使短期给药后骨骼成熟也会快速加速。
