Leonova Galina N, Pavlenko Elena V
Research Institute of Epidemiology and Microbiology, Siberian Branch of Russian Academy of Medical Sciences, Vladivostok, 690087, ul. Selskaya 1, Russia.
Vaccine. 2009 May 11;27(21):2899-904. doi: 10.1016/j.vaccine.2009.02.069. Epub 2009 Mar 3.
We assessed the humoral immunity of 290 vaccinated persons against tick-borne encephalitis (TBE). During the first year and 2 years after the primary three vaccinations the antibodies to the Far Eastern subtype tick-borne encephalitis virus strain P-73 were detected by neutralization test after immunization with FSME-Immune Inject vaccine (Baxter Vaccine AG, Austria) in 88.2% and 78.1% vaccinated persons, respectively; with Encepur((R)) Adult vaccine (Novartis Vaccines, Germany), in 100% and 100%; with the vaccine of the Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMSci (Russia), in 100% and 94.1%; with EnceVir vaccine (Russia), in 88.2% and 83.9%; and after combined vaccination, in 100% and 92.7%. The dynamics of the decrease in IgG avidity index correlated with the changes of antibody titers determined by neutralization test. After the primary vaccination course, the titers of virus-neutralizing antibodies were high (6.3-7.4 log(2)) when the avidity index of IgG antibodies were 31% and more; thus, this level can be considered immunologically significant. Two years after the primary vaccination course, the IgG avidity indexes of 60% and more can be regarded as significant on the background of the GMT decrease of virus-neutralizing antibodies. These results allow us to recommend all four vaccines for mass vaccination and an assay of IgG avidity, along with neutralization test, for a more adequate assessment of the level of postvaccination immune response.
我们评估了290名接种疫苗者针对蜱传脑炎（TBE）的体液免疫。在初次接种三针疫苗后的第一年和第二年，分别用FSME - Immune Inject疫苗（奥地利百特疫苗公司）免疫后，通过中和试验在88.2%和78.1%的接种者中检测到针对远东亚型蜱传脑炎病毒株P - 73的抗体；用Encepur((R))成人疫苗（德国诺华疫苗公司）免疫后，分别在100%和100%的接种者中检测到；用俄罗斯脊髓灰质炎和病毒性脑炎丘马科夫研究所的疫苗免疫后，分别在100%和94.1%的接种者中检测到；用EnceVir疫苗（俄罗斯）免疫后，分别在88.2%和83.9%的接种者中检测到；联合接种后，分别在100%和92.7%的接种者中检测到。IgG亲和力指数下降的动态变化与中和试验测定的抗体滴度变化相关。初次接种疫苗疗程后，当IgG抗体亲和力指数为31%及以上时，病毒中和抗体滴度较高（6.3 - 7.4 log(2)）；因此，该水平可被视为具有免疫学意义。初次接种疫苗疗程两年后，在病毒中和抗体几何平均滴度下降的背景下，IgG亲和力指数达到60%及以上可被视为具有显著意义。这些结果使我们能够推荐这四种疫苗用于大规模接种，并建议同时进行IgG亲和力检测和中和试验，以便更充分地评估疫苗接种后的免疫反应水平。
