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[俄罗斯和奥地利“免疫”公司生产的蜱传脑炎灭活培养疫苗的对比研究]

[Comparative study of inactivated cultured vaccines against tick-borne encephalitis manufactured in Russia and in Austria by the "Immuno" firm].

作者信息

Vorob'eva M S, Rasshchepkina M N, Ladyzhenskaia I P, Gorbunov M A, Pavlova L I, Bektimirov T A

出版信息

Vopr Virusol. 1996 Sep-Oct;41(5):221-4.

PMID:8967069
Abstract

Inactivated culture vaccine against tick-borne encephalitis (TBE) FSME-Immun-Inject produced in Austria ("Immuno") was compared to vaccine produced in the Institute of Poliomyelitis and viral encephalitis by immunological activity, safety, reactogenicity. In mice, no significant differences in protective activity of the vaccines were found when test-strains were diverse strains of TBE virus. Seroconversion in the sera from the vaccinated two times was not significantly different by the level of antibodies determined for both eastern and western serotypes of TBE virus.

摘要

将奥地利生产的抗蜱传脑炎(TBE)灭活培养疫苗FSME-Immun-Inject(“免疫”)与脊髓灰质炎和病毒性脑炎研究所生产的疫苗在免疫活性、安全性、反应原性方面进行了比较。在小鼠中,当测试毒株为不同的TBE病毒毒株时,未发现两种疫苗的保护活性有显著差异。通过测定TBE病毒东、西血清型的抗体水平,两次接种疫苗的小鼠血清中的血清转化无显著差异。

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