肾/胰腺联合移植后肾移植的结果

Outcome of renal grafts after simultaneous kidney/pancreas transplantation.

作者信息

Hillebrand G, Illner W D, Abendroth D, Schneeberger H, Petry I, Schleibner S, Landgraf R, Land W

机构信息

Nephrology Department, Klinikum Grosshadern, University of Munich, FRG.

出版信息

Diabetologia. 1991 Aug;34 Suppl 1:S16-7. doi: 10.1007/BF00587611.

DOI:10.1007/BF00587611

PMID:1936686

Abstract

Nineteen patients with endstage renal failure due to Type 1 (insulin-dependent) diabetes mellitus received simultaneous pancreas/kidney transplants using bladder drainage technique. Another group of 25 Type 1 diabetic patients received pancreas/kidney transplants by the duct occlusion technique. We observed a higher incidence of rejection episodes in the patients of the bladder drainage group than those in the duct occlusion group, 14 of 19 patients (74%) vs 7 of 25 (28%) respectively. Anti CD3 antibodies (OrthocloneR, OKT3) as a part of induction treatment was used more often in the bladder drainage group (58%) than in the control group (20%).

摘要

19名因1型（胰岛素依赖型）糖尿病导致终末期肾衰竭的患者采用膀胱引流技术同时接受了胰腺/肾脏移植。另一组25名1型糖尿病患者通过导管闭塞技术接受了胰腺/肾脏移植。我们观察到膀胱引流组患者的排斥反应发生率高于导管闭塞组，分别为19名患者中的14名（74%）和25名中的7名（28%）。作为诱导治疗一部分的抗CD3抗体（OrthocloneR，OKT3）在膀胱引流组（58%）中的使用频率高于对照组（20%）。