Robertson R P, Diem P, Sutherland D E
Diabetes Center, University of Minnesota Medical School, Minneapolis.
Diabetologia. 1991 Aug;34 Suppl 1:S57-60. doi: 10.1007/BF00587621.
It has been established that successful pancreas transplantation in Type 1 (insulin-dependent) diabetic patients results in normal but exaggerated phasic glucose-induced insulin secretion, normal intravenous glucose disappearance rates, improved glucose recovery from insulin-induced hypoglycaemia, improved glucagon secretion during insulin-induced hypoglycaemia, but no alterations in pancreatic polypeptide responses to hypoglycaemia. However, previous reports have not segregated the data in terms of the length of time following successful transplantation and very little prospective data collected over time in individual patients has been published. This article reports that in general there are no significant differences in the level of improvement when comparing responses as early as three months post-operatively up to as long as two years post-operatively when examining the data cross-sectionally in patients who have successfully maintained their allografts. Moreover, this remarkable constancy in pancreatic islet function is also seen in a smaller group of patients who have been examined prospectively at various intervals post-operatively. It is concluded that successful pancreas transplantation results in remarkable improvements in Alpha and Beta cell but not PP cell function that are maintained for at least one to two years.
已经证实，1型（胰岛素依赖型）糖尿病患者成功进行胰腺移植后，会出现正常但增强的阶段性葡萄糖诱导的胰岛素分泌、正常的静脉葡萄糖消失率、胰岛素诱导的低血糖后葡萄糖恢复改善、胰岛素诱导的低血糖期间胰高血糖素分泌改善，但胰腺多肽对低血糖的反应没有改变。然而，以前的报告没有根据成功移植后的时间长度对数据进行分类，而且很少有关于个体患者随时间收集的前瞻性数据发表。本文报告称，在成功维持同种异体移植的患者中，从术后三个月到术后两年进行横断面检查时，比较不同时间点的反应，总体改善水平没有显著差异。此外，在一小部分术后不同时间间隔进行前瞻性检查的患者中，也观察到胰岛功能有这种显著的稳定性。得出的结论是，成功的胰腺移植会使α细胞和β细胞功能得到显著改善，但PP细胞功能没有改善，且这种改善至少维持一到两年。
