Faris Jason E, LaCasce Ann S
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, 02115, USA.
Clin Adv Hematol Oncol. 2009 Feb;7(2):125-33.
Primary mediastinal large B-cell lymphoma is a subtype of diffuse large B-cell lymphoma, which has distinct clinical and molecular features, many of which are similar to that of nodular sclerosing/classical Hodgkin lymphoma. Anthracycline-based chemotherapy forms the foundation for treatment of this lymphoma. This review will discuss controversial topics that warrant further study, such as the superiority of third generation regimens over CHOP-based regimens (cyclophosphamide, doxorubicin, vincristine, and prednisone), the use of involved field radiotherapy, and the assessment of clinical response by positron emission tomography scans.
原发性纵隔大B细胞淋巴瘤是弥漫性大B细胞淋巴瘤的一种亚型，具有独特的临床和分子特征，其中许多特征与结节硬化型/经典霍奇金淋巴瘤相似。以蒽环类药物为基础的化疗是这种淋巴瘤治疗的基础。本综述将讨论一些值得进一步研究的争议性话题，例如第三代方案相对于基于CHOP方案（环磷酰胺、阿霉素、长春新碱和泼尼松）的优越性、受累野放疗的使用以及通过正电子发射断层扫描评估临床反应。
