Porter William W, Elie Sophia C, Matzger Adam J
Department of Chemistry and the Macromolecular Science and Engineering Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055.
Cryst Growth Des. 2008;8(1):14-16. doi: 10.1021/cg701022e.
Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN) form of CBZ-NCT, were characterized by Raman spectroscopy and powder X-ray diffraction. CBZ-SAC II, a new polymorph, was found to be in the monoclinic space group C2/c with a = 35.72 Å, b = 6.84 Å, c = 16.11 Å, and β = 98.03°. The unique feature of CBZ-SAC II is the formation of a heterosynthon between the carbamazepine and saccharin. These results are notable because CBZ-NCT and CBZ-SAC are among the most widely studied pharmaceutical cocrystals.
卡马西平与烟酰胺和糖精的共晶体显示为多晶型物。在聚合物异质核存在的情况下，从溶液中生长出了卡马西平 - 烟酰胺（CBZ - NCT）共晶体的两种多晶型物以及卡马西平 - 糖精（CBZ - SAC）共晶体的两种多晶型物。通过拉曼光谱和粉末X射线衍射对两种CBZ - NCT多晶型物，即CBZ - NCT I和CBZ - NCT的聚合物成核（PN）形式进行了表征。发现一种新的多晶型物CBZ - SAC II属于单斜空间群C2/c，a = 35.72 Å，b = 6.84 Å，c = 16.11 Å，β = 98.03°。CBZ - SAC II的独特特征是在卡马西平和糖精之间形成了一种杂合合成子。这些结果值得注意，因为CBZ - NCT和CBZ - SAC是研究最为广泛的药物共晶体之一。
