Reddy S N, Bazzocchi G, Chan S, Akashi K, Villanueva-Meyer J, Yanni G, Mena I, Snape W J
Department of Medicine, Harbor-UCLA Medical Center, Torrance.
Gastroenterology. 1991 Nov;101(5):1289-97. doi: 10.1016/0016-5085(91)90079-z.
Preprandial and postprandial colonic motility and transit (scintigraphy), with respect to the splenic flexure, were studied in 10 patients with ulcerative colitis and in 9 healthy subjects. The healthy subjects had a postprandial increase in intraluminal pressure that was significantly (P less than 0.03) greater in the descending colon than in other regions of the colon. In ulcerative colitis, the pressure was decreased in all regions compared with healthy subjects, with no significant pressure gradient among different regions. In normal subjects, transit was quiescent during fasting; eating stimulated both antegrade and retrograde transit. In ulcerative colitis, transit was variable before as well as after the meal. Both healthy subjects and patients with ulcerative colitis had more rapid emptying from the splenic flexure into the sigmoid than into the transverse colon. More frequent, low-amplitude, postprandial propagating contractions occurred in ulcerative colitis (P less than 0.05) than in healthy subjects. Propagating contractions were always antegrade and caused a rapid movement of the tracer into the sigmoid. In conclusion, ulcerative colitis is characterized by (a) decreased contractility, (b) increased low-amplitude propagating contractions, and (c) variable transit. These disturbances may accentuate the diarrhea in ulcerative colitis.
对10例溃疡性结肠炎患者和9名健康受试者进行了关于脾曲的餐前和餐后结肠动力及转运（闪烁扫描）研究。健康受试者餐后腔内压力升高，降结肠的升高幅度显著（P<0.03）大于结肠其他区域。在溃疡性结肠炎患者中，与健康受试者相比，所有区域的压力均降低，不同区域之间无明显压力梯度。在正常受试者中，禁食期间转运静止；进食刺激顺行和逆行转运。在溃疡性结肠炎患者中，餐前和餐后转运均不稳定。健康受试者和溃疡性结肠炎患者从脾曲向乙状结肠的排空均比向横结肠更快。与健康受试者相比，溃疡性结肠炎患者餐后更频繁出现低幅度的传播性收缩（P<0.05）。传播性收缩总是顺行的，并导致示踪剂快速进入乙状结肠。总之，溃疡性结肠炎的特征为：（a）收缩力降低；（b）低幅度传播性收缩增加；（c）转运不稳定。这些紊乱可能会加重溃疡性结肠炎患者的腹泻。
