Snape W J, Matarazzo S A, Cohen S
Gut. 1980 May;21(5):392-6. doi: 10.1136/gut.21.5.392.
The purpose of these studies is to determine the colonic myoelectrical and contractile response after eating a 1000 calorie meal in patients with active ulcerative colitis. During fasting, slow waves are identifiable significantly more in patients with ulcerative colitis than in normal subjects (p < 0 . 01). The predominant slow wave frequency is 6 . 1 +/- 0 . 2 cycles/min, which is similar to the normal subjects. The slow waves are not altered by eating in either group. Minimal spike or contractile activity occurs during the fasting period both in patients with ulcerative colitis and in normal subjects. In patients with ulcerative colitis, spike activity increases rapidly after eating the 1000 calorie meal (P < 0 . 01), but the maximal response is decreased and shorter in duration than in normal subjects. There is no simultaneous increase in colonic contractility above fasting levels after the meal in patients with ulcerative colitis. This is strikingly different from the simultaneous increase in contractile and spike activity (P < 0 . 01) that occurs after eating in normal subjects. These studies suggest that in ulcerative colitis (1) the colonic smooth muscle slow wave activity is intact; and (2) a disturbance in the normal colonic contractile response to eating is present despite an adequate spike response. This lack of colonic contractility may contribute to the increase in diarrhoea that occurs in these patients after eating.
这些研究的目的是确定活动性溃疡性结肠炎患者进食一顿1000卡路里的餐后结肠的肌电和收缩反应。在禁食期间，溃疡性结肠炎患者可识别出的慢波明显多于正常受试者（p<0.01）。主要慢波频率为6.1±0.2次/分钟，与正常受试者相似。两组进食后慢波均无改变。溃疡性结肠炎患者和正常受试者在禁食期间均出现最小的锋电位或收缩活动。在溃疡性结肠炎患者中，进食1000卡路里餐后锋电位活动迅速增加（P<0.01），但最大反应降低，持续时间比正常受试者短。溃疡性结肠炎患者餐后结肠收缩力没有同时高于禁食水平增加。这与正常受试者进食后收缩和锋电位活动同时增加（P<0.01）形成显著差异。这些研究表明，在溃疡性结肠炎中：（1）结肠平滑肌慢波活动完整；（2）尽管有足够的锋电位反应，但存在对进食的正常结肠收缩反应紊乱。这种结肠收缩力的缺乏可能导致这些患者进食后腹泻增加。
