2型糖尿病患者阿司匹林抵抗的研究。

A study of aspirin resistance in type 2 diabetes.

作者信息

Singla Mani Kant, Lahiri Prabir, Mukhopadhyay Pradip, Pandit Kaushik, Chaudhuri Utpal, Chowdhury Subhankar

机构信息

Department of Endocrinology, IPGME&R and SSKM Hospital, Kolkata.

出版信息

J Indian Med Assoc. 2008 Nov;106(11):720, 722-3, 740.

PMID:19368097

Abstract

Aspirin is currently known to give inadequate protection against coronary artery disease in diabetes compared to person without it. We evaluated 97 consecutive patients with type 2 diabetes for assessing laboratory aspirin resistance and attempted to assess the impact of various clinical and biochemical parameters on it. Thirty-eight patients (39.1%) were found to be less sensitive to the action of aspirin, 7 persons (7.2%) were found to be resistant and 31 persons (31.9%) were aspirin semi-responders. Only total cholesterol, LDL-cholesterol and triglyceride had statistically significant impact on aspirin resistance (p<0.05). Three persons out of 9 with some form of macrovascular disease had aspirin resistance.

摘要

目前已知，与非糖尿病患者相比，阿司匹林对糖尿病患者冠状动脉疾病的预防作用不足。我们连续评估了97例2型糖尿病患者，以检测实验室阿司匹林抵抗情况，并试图评估各种临床和生化参数对其的影响。结果发现，38例患者（39.1%）对阿司匹林作用的敏感性较低，7例患者（7.2%）存在抵抗，31例患者（31.9%）为阿司匹林半反应者。只有总胆固醇、低密度脂蛋白胆固醇和甘油三酯对阿司匹林抵抗有统计学显著影响（p<0.05）。9例患有某种形式大血管疾病的患者中有3例存在阿司匹林抵抗。