Nejsum P, Thamsborg S M, Petersen H H, Kringel H, Fredholm M, Roepstorff A
Danish Centre for Experimental Parasitology, Department of Veterinary Disease Biology, Faculty of Life Sciences, Copenhagen University, Copenhagen, Denmark.
Parasitology. 2009 May;136(6):691-7. doi: 10.1017/S0031182009005976. Epub 2009 Apr 16.
The population dynamics of Trichuris suis in pigs was studied during long-term experimental infections. Twenty-three 10-week-old pigs were inoculated with 5 T. suis eggs/kg/day. Seven, 8, and 8 pigs were necropsied at weeks 4, 8, and 14 post-start of infection (p.i.), respectively. The median numbers of worms in the colon were 538 (min-max: 277-618), 332 (14-1140) and 0 (0-4) at 4, 8, and 14 weeks p.i. respectively, suggesting an increased aggregation of the worms with time and acquisition of nearly sterile immunity. The serum levels of T. suis specific antibodies (IgG1, IgG2 and IgA) peaked at week 8 p.i. By week 14 p.i. the IgG2 and IgA antibody levels remained significantly elevated above the level of week 0. The population dynamics of T. suis trickle infections in pigs is discussed with focus on interpretation of diagnostic and epidemiological data of pigs, the use of pigs as a model for human Trichuris trichiura infections and the novel approach of using T. suis eggs in the treatment of patients with inflammatory bowel disease.
在长期实验性感染期间，对猪体内猪鞭虫的种群动态进行了研究。23头10周龄的猪每天每千克接种5个猪鞭虫卵。分别在感染开始后（p.i.）的第4、8和14周对7头、8头和8头猪进行了尸检。在感染后第4、8和14周，结肠中蠕虫的中位数分别为538（最小值 - 最大值：277 - 618）、332（14 - 1140）和0（0 - 4），这表明蠕虫随着时间的推移聚集增加，并获得了近乎无菌的免疫力。猪鞭虫特异性抗体（IgG1、IgG2和IgA）的血清水平在感染后第8周达到峰值。到感染后第14周，IgG2和IgA抗体水平仍显著高于第0周的水平。本文讨论了猪体内猪鞭虫滴度感染的种群动态，重点是对猪的诊断和流行病学数据的解释、将猪用作人类毛首鞭形线虫感染模型以及使用猪鞭虫卵治疗炎症性肠病患者的新方法。
