评估醛糖还原酶抑制对糖尿病大鼠基底膜胶原蛋白荧光增强的影响。

Evaluation of the effect of aldose reductase inhibition on increased basement membrane collagen fluorescence in diabetic rats.

Cohen M P, Klepser H, Wu V Y

University City Science Center, Philadelphia, PA 19104.

Gen Pharmacol. 1991;22(4):603-6. doi: 10.1016/0306-3623(91)90063-c.

Abstract

It has been proposed that increased fructose contributes to the formation of fluorescent pigments in diabetic tissues. 2. Since the aldose reductase inhibitor sorbinil lowers glomerular fructose concentrations, we examined the effect of sorbinil on the formation of advanced glycation end products in glomerular basement membrane of streptozotocin diabetic rats. 3. Treatment with sorbinil for 30 days after induction of diabetes did not influence the increased fluorescence observed in collagen from glomerular basement membrane of untreated diabetic rats. 4. The results suggest that nonenzymatic glycation by fructose is not a major contributor to the formation of fluorescent advanced glycation end products in basement membrane in experimental diabetes.

摘要

有人提出，果糖增加会促使糖尿病组织中荧光色素的形成。2. 由于醛糖还原酶抑制剂索比尼尔可降低肾小球中的果糖浓度，我们研究了索比尼尔对链脲佐菌素诱导的糖尿病大鼠肾小球基底膜中晚期糖基化终产物形成的影响。3. 糖尿病诱导后用索比尼尔治疗30天，并未影响未治疗的糖尿病大鼠肾小球基底膜胶原蛋白中观察到的荧光增加。4. 结果表明，在实验性糖尿病中，果糖的非酶糖基化并非基底膜中荧光晚期糖基化终产物形成的主要因素。