给予醛糖还原酶抑制剂可使糖尿病大鼠的胶原蛋白荧光降低。
Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats.
作者信息
Suárez G, Rajaram R, Bhuyan K C, Oronsky A L, Goidl J A
机构信息
Department of Orthopaedics, Mount Sinai School of Medicine, New York 10029.
出版信息
J Clin Invest. 1988 Aug;82(2):624-7. doi: 10.1172/JCI113641.
Abstract
As a consequence of an increased flux through the sorbitol pathway fructose levels rise in various tissues in diabetes. Also, in vitro nonenzymatic fructosylation of protein induces the generation of fluorescence at a rate 10 times greater than glucosylation. The administration of sorbinil, an aldose reductase inhibitor known to lower tissue fructose concentration, to experimental diabetic rats led to a decrease in the fluorescence related to advanced Maillard products in their skin collagen. This effect is consistent with the in vivo occurrence of nonenzymatic fructosylation of collagen. A potential pathogenetic role for this posttranslational modification in diabetic complications should be considered.
摘要
由于通过山梨醇途径的通量增加，糖尿病患者各种组织中的果糖水平升高。此外，蛋白质的体外非酶果糖基化诱导荧光产生的速率比糖基化高10倍。给实验性糖尿病大鼠施用索比尼尔（一种已知可降低组织果糖浓度的醛糖还原酶抑制剂），导致其皮肤胶原蛋白中与晚期美拉德产物相关的荧光减少。这种效应与胶原蛋白在体内发生非酶果糖基化一致。应考虑这种翻译后修饰在糖尿病并发症中的潜在致病作用。
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