胸腺素β4增强由细胞间黏附分子-1介导的自然杀伤细胞的细胞毒性。
Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1.
作者信息
Lee Ha-reum, Yoon Sun Young, Kang Ho-Bum, Park Sunyoung, Kim Kyung-Eun, Cho Young Hoon, Kim Seonghan, Kim Chul-woo, Cho Byung Joo, Lee Wang Jae, Bang Sa Ik, Park Hyunjeong, Cho Daeho
机构信息
Department of Life Science, Sookmyung Women's University, Hyochangwon-gil 52, Yongsan-gu, Seoul 140-742, Republic of Korea.
出版信息
Immunol Lett. 2009 Mar 24;123(1):72-6. doi: 10.1016/j.imlet.2009.02.008.
Thymosin beta 4 (T beta 4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, T beta 4's functions in relation to natural killer(NK) cells are still unknown. In this study, we show that synthetic T beta 4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that T beta 4 is a key activator of NK cell cytotoxicity.
胸腺素β4（Tβ4）是主要的G-肌动蛋白隔离蛋白，已被证明具有广泛分布和多种生物学活性。然而，Tβ4在自然杀伤（NK）细胞方面的功能仍不清楚。在本研究中，我们发现合成的Tβ4肽通过向靶细胞分泌溶细胞颗粒来增强细胞间黏附分子-1（ICAM-1）介导的NK细胞细胞毒性。这表明Tβ4是NK细胞细胞毒性的关键激活剂。
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