Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.
Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
Cells. 2022 Jun 25;11(13):2028. doi: 10.3390/cells11132028.
Endometriosis is a chronic disease that affects about 10% of women of reproductive age. It can contribute to pelvic pain, infertility or other conditions such as asthma, cardiovascular disease, breast or ovarian cancer. Research has shown that one of the conditions for the development of endometrial lesions is the dysfunction of the immune system. It appears that immune cells, such as neutrophils, macrophages, NK cells and dendritic cells, may play a specific role in the angiogenesis, growth and invasion of endometriosis cells. Immune cells secrete cytokines and defensins that also affect the endometriosis environment. This review discusses the various components of the immune system that are involved in the formation of endometrial lesions in women.
子宫内膜异位症是一种影响约 10%育龄期妇女的慢性疾病。它可导致盆腔疼痛、不孕或其他病症，如哮喘、心血管疾病、乳腺癌或卵巢癌。研究表明，子宫内膜病变发展的条件之一是免疫系统功能障碍。免疫细胞，如中性粒细胞、巨噬细胞、自然杀伤细胞和树突状细胞，可能在子宫内膜异位症细胞的血管生成、生长和侵袭中发挥特定作用。免疫细胞分泌细胞因子和防御素，也会影响子宫内膜异位症的环境。这篇综述讨论了参与女性子宫内膜病变形成的免疫系统的各个组成部分。
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