Geyfman Mikhail, Andersen Bogi
Departments of Medicine and Biological Chemistry, University of California, Irvine, California 92697, USA.
J Invest Dermatol. 2009 May;129(5):1063-6. doi: 10.1038/jid.2008.384.
The mammalian central circadian pacemaker, which is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, synchronizes and entrains clocks found in peripheral tissues. Skin harbors an active circadian clock that is under the influence of the central clock. This clock, which probably operates in most-perhaps all-types of skin cells, may influence the regulation of several circadian physiological phenomena, including cell proliferation.
哺乳动物的中枢昼夜节律起搏器位于下丘脑的视交叉上核（SCN），它使外周组织中的生物钟同步并受其调节。皮肤中存在一个受中枢生物钟影响的活跃昼夜节律钟。这个生物钟可能在大多数——或许是所有类型的皮肤细胞中发挥作用，它可能会影响包括细胞增殖在内的几种昼夜生理现象的调节。
