Department of Dermatology, Imam Khomeini Hospital, Jondishapur University of Medical Sciences, Ahvaz, Iran.
Phytother Res. 2009 Nov;23(11):1549-52. doi: 10.1002/ptr.2807.
The effects of Hypericum perforatum (St John's wort) on morphine withdrawal syndrome and comparison with clonidine have been investigated in morphine-dependent rats. Adult male Wistar rats were subjects. The frequencies of withdrawal behavioral signs (rearing, teeth chattering and jumping) induced by naloxone challenge were demonstrated in morphine dependent rats receiving Hypericum perforatum extract (HPE), saline or clonidine. The withdrawal behavioral manifestations in rats were inhibited significantly by chronic co-administration of Hypericum perforatum extract or clonidine with morphine. This study showed that clonidine was more effective than HPE at a dose of 0.4 mL/200 g and there was no significant statistical difference between the mean frequency of withdrawal signs of HPE at a dose of 0.8 mL/200 g compared with clonidine (0.2 mg/kg i.p.) but at a dose of 1.2 mL/200 g of HPE was significantly stronger than clonidine in attenuation of the morphine withdrawal syndrome.The findings suggest that HPE is capable of reducing the symptoms of opiate withdrawal and its effectiveness may be equivalent to clonidine in reducing the opiate withdrawal syndrome and may have human therapeutic potential.
贯叶金丝桃（圣约翰草）对吗啡戒断综合征的影响，并与可乐定进行了比较，在吗啡依赖大鼠中进行了研究。成年雄性 Wistar 大鼠为研究对象。在接受贯叶金丝桃提取物（HPE）、生理盐水或可乐定的吗啡依赖大鼠中，展示了纳洛酮挑战引起的戒断行为征象（竖起、牙齿打颤和跳跃）的频率。慢性共给予贯叶金丝桃提取物或可乐定与吗啡可显著抑制大鼠的戒断行为表现。这项研究表明，可乐定比 HPE 更有效，剂量为 0.4 mL/200 g，而 HPE 剂量为 0.8 mL/200 g 与可乐定（0.2 mg/kg ip）相比，戒断征象的平均频率无显著统计学差异，但 HPE 剂量为 1.2 mL/200 g 时，在减轻吗啡戒断综合征方面的作用明显强于可乐定。研究结果表明，贯叶金丝桃能够减轻阿片类药物戒断症状，其有效性可能与可乐定相当，可降低阿片类药物戒断综合征的发生，具有一定的临床应用潜力。
