Uchida S, Fukuchi I, Kato S, Nakahiro M, Yoshida H
Department of Pharmacology I, Osaka University School of Medicine, Japan.
Gerontology. 1991;37 Suppl 1:12-6. doi: 10.1159/000213292.
The effects of blockade of muscarinic acetylcholine receptors (mAChR) in rat cerebral cortex on learning and memory were studied by the use of passive and active avoidance tests. Injection of propylbenzilylcholine mustard (PrBCM) into frontal, parietal and occipital cortex decreased mAChR dose dependently, as assessed by 3H-quinuclidinylbenzilate binding studies. Bilateral injection of PrBCM into frontal and/or parietal but not occipital cortex impaired passive avoidance learning. The results suggest that intact muscarinic neurotransmission is important for registration and recall, but not retention phases of the learning and memory process. Alkylation of mAChR by PrBCM also caused impairment in the performance of active avoidance task.
通过被动和主动回避试验，研究了大鼠大脑皮质中毒蕈碱型乙酰胆碱受体（mAChR）阻断对学习和记忆的影响。用3H-喹核醇基苯甲酸酯结合研究评估，向额叶、顶叶和枕叶皮质注射丙基苄基胆碱氮芥（PrBCM）可剂量依赖性降低mAChR。向额叶和/或顶叶而非枕叶皮质双侧注射PrBCM会损害被动回避学习。结果表明，完整的毒蕈碱神经传递对学习和记忆过程的登记和回忆很重要，但对保持阶段不重要。PrBCM对mAChR的烷基化也导致主动回避任务表现受损。
