Song Yongbo, Zhou Jinping, Li Qian, Guo Yi, Zhang Lina
Department of Chemistry and Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University, Wuhan 430072, China.
Macromol Biosci. 2009 Sep 9;9(9):857-63. doi: 10.1002/mabi.200800371.
Quaternized cellulose (QC) nanoparticles were prepared in distilled water by ionic crosslinking of QC with sodium tripolyphosphate (TPP) for the first time. BSA as a model protein drug was used to investigate the loading and release features of the nanoparticles. The results indicated that QC nanoparticles had high loading efficiency and capacity for BSA. The in vitro BSA release of the QC nanoparticles displayed a burst effect in the first 2 h and then a slow continuous release. Nanoparticles with a higher DS of QC showed a decrease in particle size, an increase in zeta potential, a higher loading efficiency and a slower drug-release profile. These studies demonstrated that QC nanoparticles are potential protein carriers, and that their physicochemical properties and release profile could be easily adjusted.
首次通过季铵化纤维素（QC）与三聚磷酸钠（TPP）在蒸馏水中进行离子交联制备了季铵化纤维素纳米颗粒。以牛血清白蛋白（BSA）作为模型蛋白药物，研究了纳米颗粒的负载和释放特性。结果表明，QC纳米颗粒对BSA具有较高的负载效率和载量。QC纳米颗粒的体外BSA释放在前2小时呈现突释效应，然后缓慢持续释放。具有较高QC取代度（DS）的纳米颗粒粒径减小、zeta电位增加、负载效率更高且药物释放曲线更慢。这些研究表明，QC纳米颗粒是潜在的蛋白载体，并且其理化性质和释放曲线可以很容易地调节。
