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呋喃唑酮治疗幽门螺杆菌：它有效且安全吗？

Furazolidone therapy for Helicobacter pylori: is it effective and safe?

作者信息

De Francesco Vincenzo, Ierardi Enzo, Hassan Cesare, Zullo Angelo

出版信息

World J Gastroenterol. 2009 Apr 21;15(15):1914-5. doi: 10.3748/wjg.15.1914.

DOI:10.3748/wjg.15.1914
PMID:19370795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2670425/
Abstract

Some aspects related with the use of furazolidone as a rescue therapy for Helicobacter pylori (H pylori) infection should be remarked, especially regarding its potential oncologic risk. The inclusion of furazolidone in a treatment regimen for H pylori infection is, at least, controversial, and it does not appear to be safe.

摘要

应注意与使用呋喃唑酮作为幽门螺杆菌（H pylori）感染的挽救疗法相关的一些方面，特别是其潜在的肿瘤学风险。将呋喃唑酮纳入幽门螺杆菌感染的治疗方案至少存在争议，而且似乎并不安全。

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本文引用的文献

1
Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease.使用呋喃唑酮的四联疗法用于消化性溃疡病患者的再治疗。
World J Gastroenterol. 2008 Oct 28;14(40):6224-7. doi: 10.3748/wjg.14.6224.
2
Potential role of cysteine and methionine in the protection against hormonal imbalance and mutagenicity induced by furazolidone in female rats.半胱氨酸和蛋氨酸在预防呋喃唑酮诱导的雌性大鼠激素失衡和致突变性方面的潜在作用。
Toxicology. 2008 Jan 14;243(1-2):31-42. doi: 10.1016/j.tox.2007.09.018. Epub 2007 Sep 22.
3
The sequential therapy regimen for Helicobacter pylori eradication: a pooled-data analysis.幽门螺杆菌根除的序贯治疗方案：一项汇总数据分析。
Gut. 2007 Oct;56(10):1353-7. doi: 10.1136/gut.2007.125658. Epub 2007 Jun 12.
4
A 10-day levofloxacin-based triple therapy in patients who have failed two eradication courses.对已进行过两个根除疗程但治疗失败的患者采用基于左氧氟沙星的10天三联疗法。
Aliment Pharmacol Ther. 2005 Jul 1;22(1):45-9. doi: 10.1111/j.1365-2036.2005.02522.x.
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A third-line levofloxacin-based rescue therapy for Helicobacter pylori eradication.一种基于左氧氟沙星的三线挽救疗法用于根除幽门螺杆菌。
Dig Liver Dis. 2003 Apr;35(4):232-6. doi: 10.1016/s1590-8658(03)00059-8.
6
Attenuating effect of the monoamine oxidase inhibitor furazolidone on the anti-carcinogenetic effect of cysteamine on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
Int J Cancer. 1991 Jun 19;48(4):605-8. doi: 10.1002/ijc.2910480420.