生长激素轴与衰老：关于实际意义的机制和持续存在的问题。
The somatotropic axis and aging: mechanisms and persistent questions about practical implications.
机构信息
Department of Internal Medicine, Southern Illinois University School of Medicine, P.O. Box 19628, Springfield, IL 62794-9628, USA.
出版信息
Exp Gerontol. 2009 Jun-Jul;44(6-7):372-4. doi: 10.1016/j.exger.2009.04.001. Epub 2009 Apr 14.
Abstract
Reduced somatotropic (GH/IGF-1) signaling delays aging and extends longevity in laboratory mice. However, it is unclear whether the physiological decrease of GH and IGF-1 levels with age represents a symptom of declining neuroendocrine function, a cause of age-related alterations in body composition and functionality or a protective mechanism against age-associated disease. Although available clinical evidence does not support the use of recombinant GH as an anti-aging therapy, many studies suggest the potential utility of GH and GH secretagogues in the treatment of sarcopenia and frailty.
摘要
生长激素/胰岛素样生长因子 1（GH/IGF-1）信号通路减少可延缓衰老并延长实验小鼠的寿命。然而，目前尚不清楚随着年龄的增长，GH 和 IGF-1 水平的生理性下降是神经内分泌功能下降的表现，还是导致身体成分和功能改变的原因，或者是对抗与年龄相关疾病的保护机制。尽管现有临床证据并不支持将重组 GH 用作抗衰老疗法，但许多研究表明 GH 和 GH 促分泌素在治疗肌肉减少症和虚弱方面具有潜在的应用价值。
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