Genetic susceptibility to high myopia in Han Chinese population.

High myopia is a common ocular genetic disease in the world. The study sought to investigate the effect of the Insulin-like growth factor-1 (IGF-1) and Matrix metalloproteinase-9 (MMP-9) genes polymorphisms on high myopia in a Han population of China. This study recruited 216 unrelated Han Chinese subjects, including 103 cases with high myopia and 113 controls. Four tagging single nucleotide polymorphisms (SNPs) of and genes were genotyped using the Sequenom MassARRAY method. The chi-square test showed that the family history was significantly correlated with myopia. The SNP genotypes were all in Hardy-Weinberg equilibrium ( > 0.05). Among the four SNPs, there were statistically significant differences in the genotype and allele frequencies of between the groups ( = 0.024). The significant associations of between cases and controls also appeared after Bonferroni multiple correction ( = 0.024). Then, there were significant differences in the genotypes dominant model and codominant model of between groups ( = 0.007 and = 0.004, respectively). showed a significant difference between the cases and the controls in the recessive model ( = 0.037). Our findings indicated that of was associated with myopia in the population. The result suggested gene locus may play a role in myopia.