肾移植患者的骨病

Bone disease in kidney transplant patients.

作者信息

Huang Minna, Sprague Stuart M

机构信息

Division of Nephrology and Hypertension, NorthShore University HealthSystem, Northwestern University Feinberg School of Medicine, Evanston, IL, USA.

出版信息

Semin Nephrol. 2009 Mar;29(2):166-73. doi: 10.1016/j.semnephrol.2009.01.009.

DOI:10.1016/j.semnephrol.2009.01.009

PMID:19371807

Abstract

Chronic kidney disease and end-stage kidney disease are associated with significant disturbances in bone and mineral metabolism. With advances in the management of chronic kidney disease and improved outcomes of kidney transplantation, posttransplantation bone disease is a serious cause of morbidity in long-term survivors. The management of post-kidney transplantation bone disease is difficult because of its complex pathophysiology. Furthermore, studies of therapeutic options that may show improvement in bone mineral density have not necessarily been shown to decrease fracture risk. Evaluating and managing post-kidney transplantation bone disease remains an integral part of posttransplant medical care.

摘要

慢性肾脏病和终末期肾病与骨和矿物质代谢的显著紊乱相关。随着慢性肾脏病管理的进展以及肾移植预后的改善，移植后骨病是长期存活者发病的一个严重原因。由于其复杂的病理生理学，肾移植后骨病的管理很困难。此外，那些可能显示骨矿物质密度改善的治疗选择的研究，并不一定能降低骨折风险。评估和管理肾移植后骨病仍然是移植后医疗护理的一个重要组成部分。