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雄激素受体作用机制。

Mechanism of androgen receptor action.

作者信息

Li Jin, Al-Azzawi Farook

机构信息

Gynaecology Research Unit, University Hospitals of Leicester, Victoria Building, Leicester Royal Infirmary, Leicester LE1 5WW, United Kingdom.

出版信息

Maturitas. 2009 Jun 20;63(2):142-8. doi: 10.1016/j.maturitas.2009.03.008. Epub 2009 Apr 15.

DOI:10.1016/j.maturitas.2009.03.008
PMID:19372015
Abstract

Recent research provides a much more detailed understanding of the role of the androgen receptor in normal human development and physiology, its structure, and its functioning. This review discusses genomic and non-genomic actions of the androgen receptor, as well as their co-regulators. We also explore several clinically relevant aspects of the molecular biology of the androgen receptor and its co-regulators.

摘要

最近的研究对雄激素受体在正常人类发育和生理学中的作用、其结构及功能有了更为详细的了解。本综述讨论了雄激素受体的基因组和非基因组作用及其共调节因子。我们还探讨了雄激素受体及其共调节因子分子生物学的几个临床相关方面。

相似文献

1
Mechanism of androgen receptor action.雄激素受体作用机制。
Maturitas. 2009 Jun 20;63(2):142-8. doi: 10.1016/j.maturitas.2009.03.008. Epub 2009 Apr 15.
2
Androgens and bone.雄激素与骨骼
Curr Opin Endocrinol Diabetes Obes. 2008 Jun;15(3):250-4. doi: 10.1097/MED.0b013e3282fe6ca9.
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Key targets of hormonal treatment of prostate cancer. Part 1: the androgen receptor and steroidogenic pathways.前列腺癌激素治疗的关键靶点。第1部分:雄激素受体和类固醇生成途径。
BJU Int. 2009 Aug;104(4):438-48. doi: 10.1111/j.1464-410X.2009.08695.x. Epub 2009 Jun 24.
4
Study of androgen action in bone by analysis of androgen-receptor deficient mice.
J Bone Miner Metab. 2002;20(6):326-30. doi: 10.1007/s007740200047.
5
Effects of androgens on cardiovascular remodeling.雄激素对心血管重构的影响。
J Endocrinol. 2012 Jul;214(1):1-10. doi: 10.1530/JOE-12-0126. Epub 2012 Apr 5.
6
[Androgen function on skeletal tissues: analysis of androgen receptor-deficient mice].[雄激素对骨骼组织的作用:雄激素受体缺陷小鼠的分析]
Clin Calcium. 2006 Mar;16(3):455-60.
7
Membrane androgen receptor activation in prostate and breast tumor cells: molecular signaling and clinical impact.前列腺和乳腺肿瘤细胞中的膜雄激素受体激活:分子信号传导与临床影响。
IUBMB Life. 2009 Jan;61(1):56-61. doi: 10.1002/iub.150.
8
Anabolic responsiveness of skeletal muscles correlates with androgen receptor protein but not mRNA.骨骼肌的合成代谢反应与雄激素受体蛋白相关,而非与信使核糖核酸相关。
Can J Physiol Pharmacol. 2006 Feb;84(2):273-7. doi: 10.1139/y05-157.
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Steroid receptor control of reproductive behavior.类固醇受体对生殖行为的控制。
Horm Behav. 2004 Mar;45(3):168-72. doi: 10.1016/j.yhbeh.2003.09.013.
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Castration-resistant prostate cancer: locking up the molecular escape routes.去势抵抗性前列腺癌:阻断分子逃逸途径
Clin Cancer Res. 2009 May 15;15(10):3251-5. doi: 10.1158/1078-0432.CCR-08-1171.

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Dihydrotestosterone-androgen receptor signaling suppresses EBV-positive gastric cancer through DNA demethylation-mediated viral reactivation.双氢睾酮 - 雄激素受体信号通路通过DNA去甲基化介导的病毒再激活抑制EBV阳性胃癌。
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Tailored therapies for triple-negative breast cancer: current landscape and future perceptions.三阴性乳腺癌的个体化治疗:现状与未来展望
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 3. doi: 10.1007/s00210-025-03896-4.
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The androgen clock is an epigenetic predictor of long-term male hormone exposure.
雄激素时钟是长期雄激素暴露的一种表观遗传预测指标。
Proc Natl Acad Sci U S A. 2025 Jan 21;122(3):e2420087121. doi: 10.1073/pnas.2420087121. Epub 2025 Jan 13.
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Antioxidants (Basel). 2024 Dec 18;13(12):1556. doi: 10.3390/antiox13121556.
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Androgen Signaling in Prostate Cancer: When a Friend Turns Foe.前列腺癌中的雄激素信号传导:当朋友变成敌人时。
Endocr Metab Immune Disord Drug Targets. 2025;25(1):37-56. doi: 10.2174/0118715303313528240523101940.
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Testosterone Enhances K Currents and Airway Smooth Muscle Relaxation Induced by ATP and UTP through P2Y Receptors and Adenylyl Cyclase Pathway.睾酮通过 P2Y 受体和腺苷酸环化酶通路增强由 ATP 和 UTP 诱导的钾电流和气道平滑肌松弛。
Int J Mol Sci. 2024 Apr 24;25(9):4652. doi: 10.3390/ijms25094652.
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Insulin and the sebaceous gland function.胰岛素与皮脂腺功能。
Front Physiol. 2023 Sep 1;14:1252972. doi: 10.3389/fphys.2023.1252972. eCollection 2023.
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Androgen Receptor and Cardiovascular Disease: A Potential Risk for the Abuse of Supplements Containing Selective Androgen Receptor Modulators.雄激素受体与心血管疾病:滥用含选择性雄激素受体调节剂的补充剂的潜在风险。
Nutrients. 2023 Jul 26;15(15):3330. doi: 10.3390/nu15153330.
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Potential Therapeutic Targets for Luminal Androgen Receptor Breast Cancer: What We Know so Far.管腔雄激素受体乳腺癌的潜在治疗靶点:我们目前所了解的情况。
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The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in ageing Men.睾酮、雄激素受体和下丘脑-垂体-性腺轴在老年男性抑郁症中的作用。
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