Klastersky Jean
Department of Medicine, Institut Jules Bordet, 1000 Brussels, Belgium.
J Antimicrob Chemother. 2009 May;63 Suppl 1:i14-5. doi: 10.1093/jac/dkp075.
Why empirical therapy? Because it works! Empirical antimicrobial therapy is a reasonable, pragmatic approach to limit the ominous threat of Gram-negative sepsis in febrile neutropenic cancer patients. Empirical treatment of occult fungal infection in patients with neutropenia and persistent fever, in spite of initial broad-spectrum antimicrobial coverage, is effective but the role of pre-emptive treatment remains to be established.
为什么采用经验性治疗？因为它有效！经验性抗菌治疗是一种合理、务实的方法，可限制发热性中性粒细胞减少癌症患者革兰氏阴性菌败血症的严重威胁。尽管初始给予了广谱抗菌覆盖，但对中性粒细胞减少且持续发热患者的隐匿性真菌感染进行经验性治疗是有效的，不过抢先治疗的作用仍有待确定。
