Maekawa A, Matsushima Y, Onodera H, Shibutani M, Yoshida J, Kodama Y, Kurokawa Y, Hayashi Y
Division of Pathology, Biological Safety Research Center, National Institute of Hygienic Sciences, Tokyo, Japan.
Food Chem Toxicol. 1991 Sep;29(9):589-94. doi: 10.1016/0278-6915(91)90139-x.
The long-term toxicity/carcinogenicity of calcium lactate, a food additive, was examined in F344 rats. Calcium lactate was given ad lib. in the drinking-water at levels of 0, 2.5 or 5% to groups of 50 male and 50 female rats for two years. No clear toxic lesion was specifically caused by long-term administration of calcium lactate. No significant dose-related increase was found in the incidences of tumours in any organ or tissue. The results indicated that calcium lactate had neither toxic nor carcinogenic activity in F344 rats.
对食品添加剂乳酸钙的长期毒性/致癌性在F344大鼠中进行了研究。将乳酸钙随意添加到饮用水中，以0%、2.5%或5%的浓度分别给予50只雄性和50只雌性大鼠，持续两年。长期给予乳酸钙未引发明显的毒性损伤。在任何器官或组织中，肿瘤发生率均未发现与剂量相关的显著增加。结果表明，乳酸钙对F344大鼠既无毒性也无致癌活性。
