Bandelow B, Müller P, Rüther E
Psychiatrische Universitätsklinik Göttingen.
Fortschr Neurol Psychiatr. 1991 Aug;59(8):297-321. doi: 10.1055/s-2007-1000705.
Haloperidol, a butyrophenone derivative, was first used 30 years ago and has since become one the most frequently prescribed neuroleptics, employed in the treatment of numerous psychiatric and neurological syndromes. It has a very good antipsychotic effect; its sedative effects are moderate compared against weakly potent neuroleptics, and its vegetative side effects are only slight. In a review of the literature, the data found during the past 30 years are commented upon, such as data on pharmacodynamics, pharmacokinetics, indications, undesirable effects, interactions, dosage, contraindications and precautionary measures - all of them having implications on research on neuroleptics as a whole.
氟哌啶醇是一种丁酰苯衍生物，30年前首次使用，此后成为最常处方的抗精神病药物之一，用于治疗多种精神和神经综合征。它具有非常好的抗精神病作用；与低效价抗精神病药物相比，其镇静作用适中，植物神经副作用也很轻微。本文回顾了过去30年的文献数据，包括药效学、药代动力学、适应症、不良反应、相互作用、剂量、禁忌症和预防措施等方面的数据，所有这些对整个抗精神病药物的研究都有影响。
