Ono K, Matsumoto M, Takii M, Ishizu H
Diabetes Center, Kitakyushu Municipal Hospital of Kokura.
Fukuoka Igaku Zasshi. 1991 Aug;82(8):467-9.
Continuous subcutaneous insulin injection (CSII) is one of good methods to control unstable diabetes. In this paper, we reported a case of a patient with unstable diabetes after total pancreatectomy, to whom CSII was very effective. The case was 53 years of age, lean woman. In 1980, she had pancreatoduodenectomy for the treatment of cancer of duodenal papilla. In June, 1986, she was diagnosed as recurrence of the cancer, and undertaken total pancreatectomy. And then, insulin treatment was commended. But she readily developed hypoglycemic reactions by ordinary insulin injection once or twice a day, and glycemic control was very poor. On April 22, 1987, CSII was started. 8 units of regular insulin were given during 24 hours, and 2 units of regular insulin were added before every meal. Thereafter, the frequency of hypoglycemic reaction decreased dramatically, and HbA1c level decreased from 8.5% to 8.1% three months later. This report indicated usefulness of CSII to patients with unstable diabetes, who couldn't be controlled by ordinary insulin injection.
持续皮下胰岛素注射（CSII）是控制不稳定型糖尿病的良好方法之一。在本文中，我们报告了1例全胰切除术后不稳定型糖尿病患者，CSII对其非常有效。该病例为一名53岁的消瘦女性。1980年，她因十二指肠乳头癌接受了胰十二指肠切除术。1986年6月，她被诊断为癌症复发，并接受了全胰切除术。随后，建议进行胰岛素治疗。但她每天注射一两次普通胰岛素时很容易出现低血糖反应，血糖控制很差。1987年4月22日开始进行CSII。24小时内给予8单位正规胰岛素，每餐饭前追加2单位正规胰岛素。此后，低血糖反应的频率显著降低，三个月后糖化血红蛋白（HbA1c）水平从8.5%降至8.1%。本报告表明，CSII对无法通过普通胰岛素注射控制的不稳定型糖尿病患者有用。
