平菇提取物在实验动物模型中的抗白内障作用
Anticataractogenic effect of an extract of the oyster mushroom, Pleurotus ostreatus, in an experimental animal model.
作者信息
Isai M, Elanchezhian R, Sakthivel M, Chinnakkaruppan A, Rajamohan M, Jesudasan C Nelson, Thomas P A, Geraldine P
机构信息
Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu, India.
出版信息
Curr Eye Res. 2009 Apr;34(4):264-73. doi: 10.1080/02713680902774069.
PURPOSE
To evaluate the efficacy of Pleurotus ostreatus extract in preventing selenite-induced cataractogenesis.
METHODS
In vitro, enucleated rat lenses, divided into one control and three experimental groups (selenite only, simultaneous selenite and extract, initial extract and subsequent selenite), underwent morphological and biochemical evaluation. The anti-cataractogenic effect was also evaluated in vivo.
RESULTS
In vitro, simultaneous incubation of extract with selenite-challenged lenses caused a decrease in lens opacification by maintaining antioxidant components at near normal levels. In vivo, P.ostreatus (300 mg/kg body weight) prevented cataract in 75% of rats.
CONCLUSION
Extract of P. ostreatus prevents experimental selenite-induced cataractogenesis.
目的
评估平菇提取物在预防亚硒酸盐诱导的白内障形成中的功效。
方法
在体外，将摘除的大鼠晶状体分为一个对照组和三个实验组（仅亚硒酸盐组、亚硒酸盐与提取物同时处理组、先给予提取物后给予亚硒酸盐组），进行形态学和生化评估。还在体内评估了抗白内障作用。
结果
在体外，提取物与受亚硒酸盐挑战的晶状体同时孵育，通过将抗氧化成分维持在接近正常水平，导致晶状体混浊程度降低。在体内，平菇（300毫克/千克体重）可预防75%的大鼠发生白内障。
结论
平菇提取物可预防实验性亚硒酸盐诱导的白内障形成。
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