非霍奇金淋巴瘤细胞外基质调节因子的改变

Alterations in regulators of the extracellular matrix in non-Hodgkin lymphomas.

作者信息

Negaard Helene F S, Svennevig Katja, Kolset Svein Olav, Iversen Nina, Lothe Inger Marie Bowitz, Østenstad Bjørn, Sandset Per Morten, Iversen Per Ole

机构信息

Department of Haematology, Oslo University Hospital Ullevål, Oslo, Norway.

出版信息

Leuk Lymphoma. 2009 Jun;50(6):998-1004. doi: 10.1080/10428190902889270.

DOI:10.1080/10428190902889270

PMID:19373600

Abstract

Bone marrow angiogenesis is increased in non-Hodgkin lymphomas (NHL). Compounds affecting extracellular matrix (ECM) may modify angiogenesis. Here we investigated ECM regulators in 48 unselected NHL patients compared with 35 controls. Untreated patients had elevated (P < 0.05) serum matrix metalloproteinase (MMP) 9 and tissue inhibitor of metalloproteinase (TIMP) 1, while MMP-2, TIMP-2 and syndecan-1 were not significantly different from controls. MMP-9 mRNA was significantly up-regulated in blood mononuclear cells, while mRNA expressions of the other ECM regulators were unaltered. We found strong correlations between mRNA expressions of both vascular endothelial growth factor and fibroblast growth factor 2, and MMP-9, TIMP-1 and TIMP-2. After therapy, serum MMP-2 increased while MMP-9 decreased (P < 0.05), the others being unchanged. Several compounds affecting ECM may be involved in angiogenic activity in NHL.

摘要

非霍奇金淋巴瘤（NHL）患者的骨髓血管生成增加。影响细胞外基质（ECM）的化合物可能会改变血管生成。在此，我们对48例未经选择的NHL患者与35名对照者的ECM调节因子进行了研究。未经治疗的患者血清基质金属蛋白酶（MMP）9和金属蛋白酶组织抑制剂（TIMP）1升高（P < 0.05），而MMP-2、TIMP-2和Syndecan-1与对照者无显著差异。MMP-9 mRNA在血液单核细胞中显著上调，而其他ECM调节因子的mRNA表达未改变。我们发现血管内皮生长因子和成纤维细胞生长因子2的mRNA表达与MMP-9、TIMP-1和TIMP-2之间存在强相关性。治疗后，血清MMP-2升高而MMP-9降低（P < 0.05），其他指标未改变。几种影响ECM的化合物可能参与了NHL的血管生成活性。