肾细胞癌患者血浆和肿瘤组织中的基质金属蛋白酶及其抑制剂
Matrix-metalloproteinases and their inhibitors in plasma and tumor tissue of patients with renal cell carcinoma.
作者信息
Lein M, Jung K, Laube C, Hübner T, Winkelmann B, Stephan C, Hauptmann S, Rudolph B, Schnorr D, Loening S A
机构信息
Department of Urology, University Hospital Charité, Humboldt University, Berlin, Germany.
出版信息
Int J Cancer. 2000 Mar 15;85(6):801-4. doi: 10.1002/(sici)1097-0215(20000315)85:6<801::aid-ijc11>3.0.co;2-c.
Matrix-metalloproteinases (MMPs) are associated with invasive and metastatic behavior of several human malignant tumors. We have determined MMP-2 and MMP-9 and tissue inhibitors of MMPs (TIMP-1 and TIMP-2) in blood plasma and in renal tissue samples of patients with renal cell carcinoma (RCC) from cancerous and non-cancerous parts of the same kidney. In tumor tissue, MMP-9 and TIMP-1 were significantly higher than in normal counterparts. MMP-2 was not different between tumor tissue and normal counterparts. TIMP-2 values could not be measured. In plasma, MMP-9 concentrations were significantly higher in RCC patients than in healthy controls, MMP-2 and TIMP-2 concentrations were higher in healthy controls and TIMP-1 concentrations were not different.
基质金属蛋白酶（MMPs）与多种人类恶性肿瘤的侵袭和转移行为相关。我们测定了来自同一肾脏癌性和非癌性部分的肾细胞癌（RCC）患者血浆和肾组织样本中的MMP-2、MMP-9以及MMPs的组织抑制剂（TIMP-1和TIMP-2）。在肿瘤组织中，MMP-9和TIMP-1显著高于正常对应组织。肿瘤组织与正常对应组织之间的MMP-2无差异。TIMP-2值无法测量。在血浆中，RCC患者的MMP-9浓度显著高于健康对照，健康对照的MMP-2和TIMP-2浓度较高，TIMP-1浓度无差异。
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