• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

亚硒酸钠可提高DU - 145前列腺癌细胞中肿瘤抑制蛋白PTEN的活性。

Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells.

作者信息

Berggren Margareta, Sittadjody Sivanandane, Song Zuohe, Samira Jean-Louis, Burd Randy, Meuillet Emmanuelle J

机构信息

Department of Nutritional Sciences, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85721-0038, USA.

出版信息

Nutr Cancer. 2009;61(3):322-31. doi: 10.1080/01635580802521338.

DOI:10.1080/01635580802521338
PMID:19373605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4049328/
Abstract

Epidemiological and clinical data suggest that selenium may prevent prostate cancer; however, the cellular effects of selenium in malignant prostate cells are not well understood. We previously reported that the activity of the tumor suppressor PTEN is modulated by thioredoxin (Trx) in a RedOx-dependent manner. In this study, we demonstrated that the activity of Trx reductase (TR) is increased by sevenfold in the human prostate cancer cell line, DU-145, after 5 days of sodium selenite (Se) treatment. The treatment of DU-145 cells with increasing concentrations of Se induced an increase in PTEN lipid phosphatase activity by twofold, which correlated with a decrease in phospho-ser(473)-Akt, and an increase in phospho-Ser(370)-PTEN levels. Se also increased casein kinase-2 (CK2) activity; and the use of apigenin, an inhibitor of CK2, revealed that the regulation of the tumor suppressor PTEN by Se may be achieved via both the Trx-TR system and the RedOx control of the kinase involved in the regulation of PTEN activity.

摘要

流行病学和临床数据表明，硒可能预防前列腺癌；然而，硒在恶性前列腺细胞中的细胞效应尚未完全明确。我们之前报道过，肿瘤抑制因子PTEN的活性受硫氧还蛋白（Trx）以氧化还原依赖的方式调节。在本研究中，我们证明，经亚硒酸钠（Se）处理5天后，人前列腺癌细胞系DU-145中的硫氧还蛋白还原酶（TR）活性增加了7倍。用浓度递增的Se处理DU-145细胞，诱导PTEN脂质磷酸酶活性增加了2倍，这与磷酸化丝氨酸（473）-Akt的减少以及磷酸化丝氨酸（370）-PTEN水平的增加相关。Se还增加了酪蛋白激酶2（CK2）的活性；使用CK2抑制剂芹菜素表明，Se对肿瘤抑制因子PTEN的调节可能通过Trx-TR系统以及参与PTEN活性调节的激酶的氧化还原控制来实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/cc0921fcb67d/nihms-594135-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/cfa2920d9d99/nihms-594135-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/181024b76bc5/nihms-594135-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/8555a8e3aef8/nihms-594135-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/389dc88a46da/nihms-594135-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/c2c36325e273/nihms-594135-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/4a16104ddb17/nihms-594135-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/cc0921fcb67d/nihms-594135-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/cfa2920d9d99/nihms-594135-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/181024b76bc5/nihms-594135-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/8555a8e3aef8/nihms-594135-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/389dc88a46da/nihms-594135-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/c2c36325e273/nihms-594135-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/4a16104ddb17/nihms-594135-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8047/4049328/cc0921fcb67d/nihms-594135-f0007.jpg

相似文献

1
Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells.亚硒酸钠可提高DU - 145前列腺癌细胞中肿瘤抑制蛋白PTEN的活性。
Nutr Cancer. 2009;61(3):322-31. doi: 10.1080/01635580802521338.
2
Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.化学预防剂硒对癌细胞中硫氧还蛋白还原酶活性的调控机制
Cancer Res. 1997 Nov 1;57(21):4965-70.
3
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity.硫氧还蛋白-1与PTEN的C2结构域结合，抑制PTEN的脂质磷酸酶活性和膜结合：PTEN肿瘤抑制活性功能丧失的一种机制。
Arch Biochem Biophys. 2004 Sep 15;429(2):123-33. doi: 10.1016/j.abb.2004.04.020.
4
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.PTEN 调节的 AKT/FoxO3a/Bim 信号通路参与亚硒酸盐诱导的结直肠癌细胞中活性氧介导的细胞凋亡。
Cell Death Dis. 2013 Feb 7;4(2):e481. doi: 10.1038/cddis.2013.3.
5
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells.抑制整合素连接激酶（ILK）可抑制蛋白激酶B/Akt的激活，并诱导PTEN突变的前列腺癌细胞发生细胞周期阻滞和凋亡。
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3207-12. doi: 10.1073/pnas.97.7.3207.
6
Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line.硒对LNCaP人前列腺癌细胞系凋亡和细胞周期的氧化还原介导作用。
Cancer Res. 2001 Oct 1;61(19):7071-8.
7
Selenium and the thioredoxin and glutaredoxin systems.硒与硫氧还蛋白和谷氧还蛋白系统。
Biomed Environ Sci. 1997 Sep;10(2-3):271-9.
8
Contribution of thioredoxin reductase to T-cell mitogenesis and NF-kappaB DNA-binding promoted by selenite.硫氧还蛋白还原酶对亚硒酸盐促进的T细胞有丝分裂和NF-κB DNA结合的作用。
Antioxid Redox Signal. 2007 Jan;9(1):115-21. doi: 10.1089/ars.2007.9.115.
9
Selenite-induced apoptosis in doxorubicin-resistant cells and effects on the thioredoxin system.亚硒酸盐诱导阿霉素耐药细胞凋亡及其对硫氧还蛋白系统的影响。
Biochem Pharmacol. 2004 Feb 1;67(3):513-22. doi: 10.1016/j.bcp.2003.09.021.
10
Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.硫氧还蛋白还原酶抑制剂乙磺硒与亚硒酸钠在抑制人非小细胞肺癌细胞增殖及诱导其死亡中的协同作用。
Chem Biol Interact. 2017 Sep 25;275:74-85. doi: 10.1016/j.cbi.2017.07.020. Epub 2017 Jul 27.

引用本文的文献

1
Cetuximab-conjugated sodium selenite nanoparticles for doxorubicin targeted delivery against MCF-7 breast cancer cells.西妥昔单抗偶联亚硒酸钠纳米粒用于阿霉素靶向递送至 MCF-7 乳腺癌细胞。
Nanomedicine (Lond). 2024;19(29):2447-2462. doi: 10.1080/17435889.2024.2403962. Epub 2024 Oct 9.
2
A Study on Myogenesis by Regulation of Reactive Oxygen Species and Cytotoxic Activity by Selenium Nanoparticles.通过活性氧调节及硒纳米颗粒的细胞毒性活性对成肌作用的研究
Antioxidants (Basel). 2021 Oct 29;10(11):1727. doi: 10.3390/antiox10111727.
3
The Effect of Selenium Nanoparticles on the Osteogenic Differentiation of MC3T3-E1 Cells.

本文引用的文献

1
PTEN is destabilized by phosphorylation on Thr366.PTEN在苏氨酸366位点发生磷酸化后会变得不稳定。
Biochem J. 2007 Aug 1;405(3):439-44. doi: 10.1042/BJ20061837.
2
Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster.果蝇中硫氧还蛋白对肿瘤抑制因子PTEN活性的调控
Exp Cell Res. 2007 Apr 1;313(6):1161-71. doi: 10.1016/j.yexcr.2007.01.004. Epub 2007 Jan 12.
3
Intracellular hydrogen peroxide production is an upstream event in apoptosis induced by down-regulation of casein kinase 2 in prostate cancer cells.
纳米硒对MC3T3-E1细胞成骨分化的影响
Nanomaterials (Basel). 2021 Feb 23;11(2):557. doi: 10.3390/nano11020557.
4
Treatment Stratification of Patients with Metastatic Castration-Resistant Prostate Cancer by Machine Learning.基于机器学习的转移性去势抵抗性前列腺癌患者的治疗分层
iScience. 2020 Feb 21;23(2):100804. doi: 10.1016/j.isci.2019.100804. Epub 2019 Dec 26.
5
Emerging Anticancer Potentials of Selenium on Osteosarcoma.硒在骨肉瘤中的新兴抗癌潜力。
Int J Mol Sci. 2019 Oct 25;20(21):5318. doi: 10.3390/ijms20215318.
6
Organoids Increase the Predictive Value of Cancer Chemoprevention Studies for Outcome.类器官提高了癌症化学预防研究对结果的预测价值。
Front Oncol. 2019 Feb 20;9:77. doi: 10.3389/fonc.2019.00077. eCollection 2019.
7
In Vitro Antibacterial Spectrum of Sodium Selenite against Selected Human Pathogenic Bacterial Strains.亚硒酸钠对选定的人类致病细菌菌株的体外抗菌谱
Scientifica (Cairo). 2016;2016:9176273. doi: 10.1155/2016/9176273. Epub 2016 Mar 15.
8
Influence of concurrent medications on outcomes of men with prostate cancer included in the TAX 327 study.TAX 327研究中同时使用的药物对前列腺癌男性患者治疗结果的影响。
Can Urol Assoc J. 2013 Jan-Feb;7(1-2):E74-81. doi: 10.5489/cuaj.267.
9
PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.PTEN 调节的 AKT/FoxO3a/Bim 信号通路参与亚硒酸盐诱导的结直肠癌细胞中活性氧介导的细胞凋亡。
Cell Death Dis. 2013 Feb 7;4(2):e481. doi: 10.1038/cddis.2013.3.
10
PTEN modulators: a patent review.PTEN 调节剂：专利研究综述。
Expert Opin Ther Pat. 2013 May;23(5):569-80. doi: 10.1517/13543776.2013.768985. Epub 2013 Feb 5.
细胞内过氧化氢的产生是前列腺癌细胞中酪蛋白激酶2下调诱导凋亡的上游事件。
Mol Cancer Res. 2006 May;4(5):331-8. doi: 10.1158/1541-7786.MCR-06-0073.
4
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells.阐明硒使前列腺癌细胞中Akt失活的机制。
Mol Cancer Ther. 2006 Feb;5(2):246-52. doi: 10.1158/1535-7163.MCT-05-0376.
5
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.酪蛋白激酶和糖原合酶激酶3β对肿瘤抑制因子磷酸酶和张力蛋白同源物（PTEN）的协同磷酸化作用。
J Biol Chem. 2005 Oct 21;280(42):35195-202. doi: 10.1074/jbc.M503045200. Epub 2005 Aug 17.
6
Protein kinase CK2 phosphorylates and upregulates Akt/PKB.蛋白激酶CK2使Akt/PKB磷酸化并上调其表达。
Cell Death Differ. 2005 Jun;12(6):668-77. doi: 10.1038/sj.cdd.4401604.
7
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity.硫氧还蛋白-1与PTEN的C2结构域结合，抑制PTEN的脂质磷酸酶活性和膜结合：PTEN肿瘤抑制活性功能丧失的一种机制。
Arch Biochem Biophys. 2004 Sep 15;429(2):123-33. doi: 10.1016/j.abb.2004.04.020.
8
Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt pathway and Rac1.
J Biol Chem. 2003 Oct 10;278(41):39615-24. doi: 10.1074/jbc.M304095200. Epub 2003 Aug 1.
9
Serum selenium and risk of prostate cancer in U.S. blacks and whites.美国黑人和白人的血清硒水平与前列腺癌风险
Int J Cancer. 2003 Feb 20;103(5):664-70. doi: 10.1002/ijc.10866.
10
Distinct effects of methylseleninic acid versus selenite on apoptosis, cell cycle, and protein kinase pathways in DU145 human prostate cancer cells.甲基亚硒酸与亚硒酸盐对DU145人前列腺癌细胞凋亡、细胞周期及蛋白激酶途径的不同影响。
Mol Cancer Ther. 2002 Oct;1(12):1059-66.