Lee Ta-Jen, Huang Shiang-Fu, Chang Po-Hung
Department of Otolaryngology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan.
Ann Otol Rhinol Laryngol. 2009 Mar;118(3):211-7. doi: 10.1177/000348940911800309.
Isolated sphenoid sinus aspergilloma (ISSA) is a form of fungal sinus infection that is distinct from allergic fungal sinusitis, invasive fungal disease, and Aspergillus granulomas. In this study, we identify the characteristics of patients with ISSA to achieve timelier intervention for this easily neglected disease.
In a retrospective study of patients with ISSA in our institution (1995 to 2006), 12 were identified.
Sixty-seven percent of our patients were more than 50 years of age, and a female preponderance was noted. Headache and postnasal drip were the two most common symptoms, and the samples from 78% of our patients with postnasal drip were blood-tinged. Computed tomographic scanning provided a sensitivity of 64%, whereas endoscopic examination failed to identify abnormalities in any patients.
Four characteristics were identified in the diagnosis of ISSA: female; usually above 50 years of age; with postnasal drip (especially blood-tinged); and headache (particularly periorbital or retro-orbital).
孤立性蝶窦曲霉菌瘤（ISSA）是一种真菌性鼻窦感染形式，有别于变应性真菌性鼻窦炎、侵袭性真菌病和曲霉菌肉芽肿。在本研究中，我们确定ISSA患者的特征，以便对这种易被忽视的疾病进行更及时的干预。
对我院（1995年至2006年）的ISSA患者进行回顾性研究，共确定了12例患者。
我们的患者中有67%年龄超过50岁，且女性居多。头痛和鼻后滴漏是最常见的两种症状，在有鼻后滴漏的患者中，78%的样本带有血丝。计算机断层扫描的敏感度为64%，而内镜检查未发现任何患者有异常。
在ISSA的诊断中确定了四个特征：女性；通常年龄在50岁以上；有鼻后滴漏（尤其是带有血丝）；以及头痛（特别是眶周或眶后头痛）。
