Division of Renal Disease and Hypertension, University of Colorado Denver, Aurora, Colorado, USA.
Contemp Clin Trials. 2009 Sep;30(5):392-9. doi: 10.1016/j.cct.2009.04.003. Epub 2009 Apr 16.
Much has been learned about the pathophysiological state that underlies the development of increased total body volume and edema in left ventricular failure. Very little, however, is known about the mechanism underlying systemic hypervolemia in patients with isolated right ventricular dysfunction. In this manuscript, we describe our randomized clinical trial to assess the relationship between severity of pulmonary arterial hypertension and neurohormonal activation, total plasma volume and renal function. We assess the role of aldosterone and vasopressin in volume retention in patients with pulmonary arterial hypertension with right ventricular failure. As understanding of the pathogenesis of left ventricular failure has been associated with improved therapies, the better understanding of the mechanisms of isolated right ventricular cardiac failure will also lead to improved patient care.
关于左心室衰竭时全身血容量增加和水肿形成的病理生理状态，已经有了很多了解。然而，对于单纯右心室功能障碍患者全身性血容量过多的机制却知之甚少。在本文中，我们描述了一项随机临床试验，以评估肺动脉高压严重程度与神经激素激活、全血浆容量和肾功能之间的关系。我们评估了醛固酮和血管加压素在肺动脉高压伴右心衰竭患者容量潴留中的作用。随着对左心室衰竭发病机制的了解，已经出现了改善治疗的方法，因此，对单纯右心室心力衰竭机制的更好理解也将导致患者护理的改善。
