一种p75神经营养因子受体（p75(NTR)）的枢转模式提升洞察力。
A p75(NTR) pivoting paradigm propels perspicacity.
作者信息
Barker Philip A
机构信息
Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, QC H3A 2B4, Canada.
出版信息
Neuron. 2009 Apr 16;62(1):3-5. doi: 10.1016/j.neuron.2009.04.005.
PMID:19376060
Abstract
The p75 neurotrophin receptor (p75(NTR)) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al. show that p75NTR functions as a covalently crosslinked dimer to transduce NGF-induced signaling events.
摘要
p75神经营养因子受体（p75(NTR)）参与众多神经元信号传导通路，但其基本信号传导机制尚不清楚。在本期《神经元》杂志中，比拉尔等人表明，p75NTR作为一种共价交联二聚体发挥作用，以转导神经生长因子（NGF）诱导的信号事件。
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